Genomics and precision medicine, global trends to consider with NHSO | Hfocus.org

HITAP Technology Evaluation Genomics and precision medicine found “worth it” in finding patients with severe symptoms with no known cause. It is currently under consideration by the NHSO, with examples of past practice emerging.

Genomics and precision medicine, global trends

“Genomics and precision medicine (Precision Public health) are global trends. Today, all over the world, this is considered an alternative medicine.” Dr. Sakarn Bunnag, Deputy Director General of the Department of Medical Services Speaking at the academic seminar on Genomics and Precision Medicine (GENOMICS AND PRECISION MEDICINESEMINAR 2024) organized by the Department of Medical Services on August 19, 2024 at the Amari Don Mueang Airport Hotel.

Precision Public health is a technology that has many uses, such as risk warnings. Including cancer, genetic diseases, as well as chronic non-communicable diseases or NCDs, it helps to determine who is at high or low risk. which warns of risks Screening for diseases that make them known quickly The better the treatment. and treatment costs will be lower

Hightap evaluates genomics technology and finds it “worth it”

while Prof. Dr Worasak Chotile Sak Vice Dean for Research Faculty of Medicine Chulalongkorn University Provide additional knowledge that Someone published a prediction at the end of 2023 that by 2030 or another 5-6 years everyone would know their own genome. and the Science Council The World Health Organization (WHO) has referred to genomics as the first technology to improve global health. It is the study of the genetic material code. For patients with acute, severe symptoms of unknown cause

“From the evaluation, it was decided that it was “value. Sak said

Prof. said. This allows screening for a greater number of diseases. Currently, there are about 40 disease screening in Thailand using biochemical methods now, England is taking this issue to study benefits and cost-effectiveness for further use. As for Thailand, it is still in the research stage. For people who are not babies Genetic testing can be useful, for example, if you know you have genes that make you around 200 times more likely than the general population to get colon cancer or are at risk for cardiac arrhythmias. There will be another way of life to protect, etc.

Examples of genomics applications

Prof. Dr. Worasak Give an example of practice Last week, a case of type 2 diabetes was published, in which some people were treated less well than others “G6PD enzyme deficiency”. this state. It is a form of Public Health Precision.

Regarding genetic diseases This is a disease with a low frequency and at least 80% of these diseases appear less than 1 in a million, but there are many diseases. Currently, there is only knowledge of more than 7,000 diseases, but in fact there will be more than 10,000 diseases in Thailand, 5-8% of the population, or about 5 million people have one of the rare diseases them, 80%, related to genetic components. Currently, there are tools that allow us to find out which genetic elements cause this disease. Enable medical staff A diagnosis can be made and the appropriate treatment can be given in a timely manner.

or seriously ill patients who were previously medical personnel Use all available tools to investigate. It was found that most of them were unable to find the cause. One group of patients may die of unknown causes. Because I didn’t know what was wrong, I couldn’t handle it. But assuming that there are no external factors, there is a chance that it is caused by internal factors So, when this happens Then proceed with a genetic code test to find the cause first It was found that 46% were confirmed. This leads to changes in treatment and treatment outcomes.

For example, a 2-year-old patient was fine at birth. But when the mother started eating other foods that contained sugar which is sucrose which is a combination of glucose and fructose. When the genetic code was analyzed, it was found that the child had only a small abnormality in the gene, causing the disease and was unable to metabolize fructose, resulting in toxicity. The child almost died and would likely have died too if a diagnosis could not be made. This leads to a very simple treatment: do not expose children to fructose and sucrose. So far, the child has been diagnosed for about 3 years, saving his life.