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Genetic factors play a role in symptoms of loss of sense of smell and sense of taste.
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GridHEALTH.id – Since the start of the pandemic, one of the Covid-19 symptoms the most common and interesting to observe is the tendency of viruses to cause loss of taste or smell.
For many, it is their first clue that they are infected. Scientists still aren’t sure why this is (and it’s becoming less common with the Omicron variant)‚ but a new study suggests that the answer may be written, at least in part, in our genes.
loss of smell (anosmia) and loss of taste (ageusia) is a symptom identified in Covid-19 patients in the early stages of infection.
According to Johns Hopkins Medicine, symptoms can range from not being able to smell or taste at all to a reduced ability to smell or taste certain things sweet, sour, bitter or salty.
In some cases, the taste or smell is usually pleasant. may be unpleasant.
In the study, researchers at genomics company 23andMe looked at nearly 70,000 US and UK residents who reported positive for Covid-19. Sixty-eight percent of them said they lost their sense of smell or taste during illness.
Scientists compare the genetic information of people who loss of sense of smell and those who do not.
They identified areas in the genome between two genes—UGT2A1 and UGT2A2—that are associated with losing or retaining these senses.
Both genes are expressed in nasal tissue and are involved in olfaction and aroma metabolism. Having the genetic variant increases the risk of loss of taste or smell by 11%.
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Researchers aren’t sure exactly how UGT2A1 and UGT2A2 are involved, but they may affect the makeup of those nasal cells and their ability to withstand or be affected by the Covid-19 virus.
“How we get from infection to loss of smell is still unclear,” says Dr. Justin Turner, a professor of otolaryngology at Vanderbilt University, told NBC News.
“Preliminary data suggest that the supporting cells of the olfactory epithelium are the most heavily infected by the virus, and this may lead to the death of the neurons themselves,” he said.
“But we don’t really know why and when it happens, and why it appears to occur in certain individuals.”
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