Objective: To assess the impact of hepatitis B virus (HBV) infection in women on the results of In Vitro Fertilization (IVF).
Methods: An observational, single-center, case-control cohort study conducted between 2012 and 2019 compared the outcome of the first cycle of IVF between 64 women infected with HBV and 128 HIV-negative controls. Transfers of frozen embryos performed within 18 months of the puncture were included. The exclusion criteria were severe infections, viral co-infection in women, viral infection in their partner, absence of fresh embryo transfer. Matching was performed according to age, type of primary or secondary infertility, conventional IVF or micro-injection technique and date of attempt. The main analysis focused on cumulative births.
Results: The clinical and ovarian stimulation characteristics were comparable except for a longer infertility time in case of HBV infection. The birth rate in the HBV group compared to controls was not different after transfer of fresh (14.06 vs 25.00% p = 0.08) or frozen (4.17 vs 18.92% p = embryos) embryos. 0.08) but significantly decreased in cumulative analysis (15.63 vs 35.94% p = 0.003). HBV infection was negatively associated with the birth rate in multivariate analysis OR = 0.38 (95% CI 0.14-0.92) p <0.05. Implantation rates were lower in the HBV versus controls group, both in fresh (14.89 vs 27.72% p = 0.02) and frozen (3.03 vs 21.65% p = 0) embryo transfers. , 01).
Conclusion: This study supports an unfavorable impact of HBV infection in women on cumulative birth rates after IVF.
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