FKUI medical doctors examine intermittent low oxygen publicity as a risk to forestall kidney injury in sufferers with sleep apnea – College of Drugs, College of Indonesia

Hypoxia, or lack of oxygen, typically happens in individuals who undergo Obstructive sleep apnea (OSA) and in low air stress environments. Persistent hypoxia can be identified to trigger injury to kidney perform. The prevalence of OSA reached 57% amongst circumstances of kidney injury, indicating a big relationship between hypoxic situations and diminished kidney perform.

In OSA syndrome, hypoxia happens every so often, that’s every so often with regular oxygen provide situations (normoxia). That is totally different from continual hypoxia that happens with out interruption. Intermittent hypoxia is commonly skilled by individuals who stay or work in mountainous areas or by pilots who should fly at sure altitudes. To beat the chance of hypoxia, pilots bear coaching precautionthat’s, periodic publicity to delicate hypoxia to extend the physique’s resistance to subsequent hypoxia.

The newest analysis Abdul Halim Sadikin, S.Si, M.Biomed, a participant within the Doctoral Analysis Program in Biomedical Sciences, College of Drugs, College of Indonesia (FKUI), revealed that publicity to intermittent hypobaric hypoxia can induce modifications within the kidneys. This research goals to guage the impact of hypoxia on oxidative stress, glucose metabolism, and vascularization within the kidneys.

This analysis was completed by exposing experimental animals to hypoxic situations every so often. The management group consisted of experimental animals that didn’t expertise hypoxia. The outcomes confirmed that the kidney might adapt to hypoxia after preconditioning. There was a rise in protein ranges related to hypoxic adaptation within the group that skilled two intermittent hypoxias. This analysis additionally discovered that oxidative stress that usually happens in hypoxic situations might be diminished within the kidneys by precaution.

“Intermittent hypoxia seems to have the ability to cut back oxidative stress within the already uncovered kidney precaution“mentioned Abdul Halim. As well as, modifications in glucose metabolism that normally happen in hypoxic situations didn’t happen within the kidneys of experimental animals that underwent preconditioning. The parameters of glucose metabolism confirmed stability with out unfavourable modifications. Examination of kidney tissue beneath a microscope didn’t present any tissue injury.

In conclusion, the kidneys are experiencing precaution Hypoxia by way of periodic hypoxic publicity is ready to change hypoxic situations and keep survival. This discovery opens up attainable makes use of precaution hypoxia as a substitute remedy for individuals affected by OSA syndrome to forestall attainable kidney injury. Subsequently, precaution hypoxia might be an necessary prevention technique for these at excessive threat of growing hypoxia, both attributable to medical or environmental situations.

Abdul Halim efficiently defended his thesis entitled “Results of Publicity to Intermittent Hypobaric Hypoxia: A Examine of Modifications to Oxidative Stress, Glucose Metabolism, and Vascularization within the Kidneys” in an open doctoral promotion session within the third Flooring Corridor of the IMERI-FKUI Constructing , Jakarta, on 18 July 2024. Efficiently answered complaints and questions from the inspection staff with Dr. Dr. Wawaimuli Arozal, M.Biomed., Pharm.D.with trial staff members consisting of Dr. Dewi Sukmawati, M.Kes., Ph.D.; Prof. Dr. Dr. Ninik Mudjihartini, M. Biomed.; and visitor examiners from Tarunegara College, viz Prof. Dr. Frans Ferdinand, MS.

This session was chaired by the Dean of FKUI, Prof. Dr. Dr. Ari Fahrial Syam, Sp.PD(Ok)by promoters Prof. Dr. Dr. Ani Retno Prijanti, MS.in addition to co-promoters Prof. Dr. Dr. Sri Widia A. Jusman, MS., and TNI First Marshal Dr. Dr. Wawan Mulyawan SpBS, SpKP, AAK.

Prof. Ani Retno because the promoter additionally delivered her feedback. “Congratulations to Abdul Halim Sadikin who’s now a physician. This analysis was impressed by Dr. Halim’s curiosity in aerospace, during which pilots and OSA sufferers alike skilled hypoxic ranges every so often. Apparently, if remedy publicity to hypoxia repeated at instances, and solely completed for lower than 5 minutes, causes higher kidney adaptation. Nevertheless, it isn’t but identified whether or not (if remedy “completed) greater than 4 instances, whether or not it is good or not, so extra analysis must be completed,” mentioned Prof. Ann Retno.

(FKUI Public Relations)