The University of Oulu in Finland announced today that researchers have developed a new method to create functional blood vessels in laboratory organoids.
Organoids are simplified miniatures of organs created in laboratories to mimic the basic functions and structure of real organs. The addition of blood vessels is crucial for the organoids to more closely resemble the function of real organs, enhancing their potential in medical research.
To create the blood vessels, the Finnish university researchers used chick embryo chorioallantoic membrane (CAM) and a specialized microdevice. “During their development in the chicken embryo membrane, blood vessels not only form but are connected to the circulatory system to receive oxygen,” explained Seppo Vainio, Professor of Developmental Biology at the University of Oulu.
He emphasized that with this particular method, vascularized organelles can be transferred to artificial growth platforms while keeping their blood vessel network intact.
The technique tested in kidney organoids marks a major advance in organoid growth technology. With functioning blood vessels, organoids behave more like real organs, making them especially valuable in studying disease and testing new drugs. The University of Oulu believes that this innovation will accelerate scientific research on kidney failure, cancer, diabetes and hypertension.
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