Gradual loss of brain tissue is a natural part of aging, but recent and ongoing research has shown that neural connections decline more rapidly in some people as they reach middle age. age
The 27-year study, one of the longest ever, which included brain scans of participants – aged between 20 and 76 – revealed that some people’s neural connections decline faster than others others as they are middle aged.
Research coordinated by experts from Johns Hopkins University, in the US, showed that people with type 2 diabetes lost much more white matter over time than the rest, because the risk of ‘ development of moderate cognitive impairment (MCI) 41% higher.
And people with biomarkers of dementia in their cerebrospinal fluid had a nearly 50 percent higher risk of dementia, a report published in the journal JAMA Network.
If there were both diabetes and biomarkers of amyloid plaques (which are related to Alzheimer’s disease), that risk increased to 55 percent.
Participants who experienced the greatest year-over-year reduction in white matter volume were significantly more likely to develop MCI symptoms.
Previous studies have also shown that significant white matter loss is linked to cases of depression and that metabolic disturbances can increase a person’s risk of cognitive decline, but this is the first study to show a synergistic relationship between the disease sugar and amyloid plaques in relation to their effect on white matter.
“These findings indicate that white matter volume changes are closely related to cognitive function during aging, suggesting that white matter decline may play a critical role in dementia cognitive,” wrote the study authors.
“Since insulin resistance plays an essential role in the formation of amyloid plaques, diabetes can promote the pathology of Alzheimer’s disease, leading to an earlier evolution from normal cognition to MCI,” he said. they say.
2024-11-27 22:05:00
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