Exploring Peptides for Weight Loss: Wegovy, Zepbound, and More
In the world of weight loss medications, two names have been making waves lately: Wegovy and Zepbound. Both of these drugs have one thing in common – they contain peptides that are believed to aid in weight loss. Peptides, which are small chains of amino acids, play various roles in the body and can act as signaling molecules, hormones, and enzymes. While not all peptides are designed for weight loss, research has shown that many of them have this beneficial side effect.
To understand how peptides work for weight loss, we spoke to experts in the field. Keri Gans, R.D., author of The Small Change Diet, explains that peptides are structurally similar to proteins but smaller in size. They can be found in a wide range of products, including skincare serums. Christoph Buettner, M.D., Ph.D., chief of the division of endocrinology at Rutgers Robert Wood Johnson Medical School, adds that peptides are involved in various biological processes within the body.
So, do peptides actually work for weight loss? According to Dr. Buettner, the answer is yes, but not all peptides have this effect. Just like drugs, some peptides are specifically formulated for weight loss, while others are not. Mir Ali, M.D., a bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center, explains that peptides that aid in weight loss typically slow down food movement through the gut and reduce cravings.
There are several types of peptides that have been found to be effective for weight loss. GLP-1 receptor agonist medications, such as semaglutide (Ozempic and Wegovy), stimulate peptide production in the body to slow stomach emptying. Dual GIP/GLP-1 receptor agonists, like tirzepatide (Mounjaro and Zepbound), target digestion, hunger, and satiety. These medications have been approved by the FDA for weight loss and have shown promising results in clinical trials.
Semaglutide, which includes Ozempic and Wegovy, has been found to help people lose up to 14 pounds. While Ozempic is primarily used to manage blood sugar levels in patients with type 2 diabetes, Wegovy is specifically approved for weight loss. Adults on Wegovy have been shown to lose an average of 15% of their body weight or 35 pounds.
Tirzepatide, available as Mounjaro and Zepbound, targets both GLP-1 and GIP receptors in the body. During a 17-month clinical trial, participants on Zepbound lost up to 48 pounds. Liraglutide, sold as Saxenda, is another GLP-1 receptor agonist approved for weight loss. Research has shown that one out of three people who take Saxenda lose more than 10% of their body weight.
While these FDA-approved peptides require a prescription, there are also non-regulated supplements available on the market. However, it is crucial to do thorough research and consult with a healthcare professional before considering any non-FDA-approved options.
As with any medication, there are potential side effects to be aware of when using peptides for weight loss. Gastrointestinal issues, such as nausea, cramping, constipation, and diarrhea, are common but usually resolve over time. Other side effects may include low blood sugar, injection site reactions, headache, dizziness, and fatigue. It’s important to start with a lower dose and gradually increase it to minimize these effects.
In rare cases, some individuals may experience more severe side effects. Therefore, it is essential to have a discussion with your doctor to weigh the pros and cons of each medication before making a decision.
In conclusion, peptides have shown promise in aiding weight loss. FDA-approved medications like Wegovy, Zepbound, and Saxenda have demonstrated significant results in clinical trials. However, it is crucial to consult with a healthcare professional and follow their guidance when considering these medications. Peptides can be a valuable tool in the journey towards weight loss, but they should always be used under medical supervision.
