A recent review revealed treatments for Coronavirus, published in a journal International Immunopharmacology The benefit of interferons in the fight against Corona cases Severe.
While most infections are asymptomatic or mild, they are transmitted to viral pneumonia, acute respiratory distress syndrome and death in a small but significant minority.
Interferon therapy–
Interferons in immunity
Interferons are natural proteins that have a wide range of actions against viruses and inflammatory processes, and they bind to specific cell surface receptors to activate the JAK-STAT pathway, which in turn mediates the transcription of IFN-stimulating genes (ISGs). There are three types, types I and II, are pro-inflammatory, and facilitate the destruction of infected cells. , Inactivating viruses with antibodies, and cleaning up cellular and viral debris.
The third type is anti-inflammatory, it prevents virus replication within infected cells and enhances the integrity of the epithelial barrier.
Thus the first type is necessary for early viral containment inside infected cells, but it is associated with a lethal pathway in the current infection, due to the irregular immune response.
According to a Chinese study, early use of interferon could reduce in-hospital deaths when given early, but in the later stages, the mortality rate increased in COVID-19.
Interferons can also be useful in viral diseases such as hepatitis and may reduce mortality and shorten the duration of the disease CoronaTrials for its inhalable form are being conducted in patients with COPD or asthma, with very encouraging results.
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