The Dr. Marty Makary, Professor at Johns Hopkins Universitya member of the National Academy of Medicine, today highlighted the content of an article published on PubMed.gov and in the Journal of Virology signed by him Dr. Yamamoto, where, through a public letter, he requests that they stop inoculating booster doses due to the decrease in immune function detected after eight months in patients with two doses.
Specifically, the letter signed by Dr. Yamamoto refers to the information given by studies published in The Lancet and has pointed out that “the immune function among the vaccinated individuals, after eight months, after the administration of the two doses of the Covid vaccine, was lower than among the unvaccinated.” In addition, he has added to his comment the reference to the European Medicines Agency, where he notes: “Frequent booster injections could negatively affect the immune response.”
“immune function among vaccinated individuals 8mo. after the administration of two doses of COVID vaccine was lower than that among the unvaccinated”.
According to European Med Agency, “frequent booster shots could adversely affect the immune response” https://t.co/NoVN4PdSi3
— Marty Makary MD, MPH (@MartyMakary) July 20, 2022
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In your post, you reference the article published in PubMed which can be read here. It has also been published in virologyj.biomedcentral.com
The article, signed by El Dr. Jenki Yamamotois titled: “Adverse effects of vaccines against COVID-19 and measures to prevent them”.
The summary of the article points to the one recently published by The Lancet, on the effectiveness of vaccines and in which it was pointed out, in turn, “the decrease in immunity from vaccines over time.” “The study showed that immune function among vaccinated individuals 8 months after administration of two doses of the COVID-19 vaccine was lower than that of unvaccinated individuals,” Yamamoto notes.
It is precisely this part that Dr. Makary has underlined. And he also recalled that “According to the recommendations of the European Medicines Agency, frequent booster injections of COVID-19 could negatively affect the immune response and may not be feasible.”
The study also notes that “Decreased immunity may be due to several factors, including N1-methylpseudouridine, spike protein, lipid nanoparticles, antibody-dependent enhancement, and the original antigenic stimulus. These clinical alterations may explain the reported association between COVID-19 vaccination and herpes zoster.”
Suspend additional booster shots
The doctor Kenji Yamamoto proposes in his article that, as a safety measure: “additional booster vaccinations should be suspended. In addition, the date of vaccination must be recorded in the clinical history of the patients.”
He explains in his study that several practical measures have been reported to prevent a decline in immunity: “limiting the use of non-steroidal anti-inflammatory drugs, including paracetamol to maintain low body temperature, appropriate use of antibiotics, smoking cessation, stress management, and limiting the use of lipid preparations, including propofl, which can cause perioperative immunosuppression.”
The doctor warns in his article that “vaccination against COVID-19 is an important risk factor for infections in critically ill patients.”
Full article content
Dear editor,
The coronavirus disease (COVID-19) pandemic has led to the widespread use of genetic vaccines, including mRNA and viral vector vaccines. In addition, booster vaccines have been used, but their efficacy against the highly mutated spike protein of Omicron strains is limited. Recently, The Lancet published a study on the effectiveness of COVID-19 vaccines and the decline in immunity over time. [ 1]. The study showed that immune function among vaccinated people 8 months after administration of two doses of the COVID-19 vaccine was lower than that of unvaccinated people. These findings were more pronounced in older adults and individuals with pre-existing conditions. According to the recommendations of the European Medicines Agency, frequent booster injections of COVID-19 could negatively affect the immune response and may not be feasible. [ 2 ]. Several countries, including Israel, Chile and Sweden, offer the fourth dose only to older adults and other groups instead of all people [ 3 ].
The decrease in immunity is caused by several factors. First, N1-methylpseudouridine is used as a substitute for uracil in the genetic code. The modified protein can induce the activation of regulatory T cells, resulting in decreased cellular immunity. [ 4 ]. Therefore, spike proteins are not degraded immediately after administration of mRNA vaccines. Spike proteins present in exosomes circulate throughout the body for more than 4 months [ 5 ]. Additionally, in vivo studies have shown that lipid nanoparticles (LNPs) accumulate in the liver, spleen, adrenal glands, and ovaries [ 6 ]and that the mRNA encapsulated in LNP is highly inflammatory [ 7]. Newly generated antibodies to the spike protein damage cells and tissues that are primed to produce spike proteins [ 8 ]and vascular endothelial cells are damaged by spike proteins in the bloodstream [ 9 ]; this can damage organs of the immune system, such as the adrenal gland. In addition, antibody-dependent enhancement can occur, in which infection-enhancing antibodies attenuate the effect of neutralizing antibodies in preventing infection. [ 10 ]. The original antigenic sin [ 11 ], that is, the residual immune memory of the Wuhan-type vaccine may prevent the vaccine from being sufficiently effective against the variant strains. These mechanisms may also be involved in the exacerbation of COVID-19.
Some studies suggest a link between COVID-19 vaccines and reactivation of the virus that causes shingles [ 12 , 13 ]. This condition is sometimes called vaccine-acquired immunodeficiency syndrome. [ 14]. Since December 2021, in addition to COVID-19, the Department of Cardiovascular Surgery at Okamura Memorial Hospital, Shizuoka, Japan (hereinafter referred to as “the institute”) has encountered cases of infections that are difficult to control. For example, there were several cases of suspected inflammatory infections after open heart surgery, which could not be controlled even after several weeks of multiple antibiotic use. The patients showed signs of being immunocompromised and there were some deaths. The risk of infection may increase. Various medical algorithms to assess postoperative prognosis may need to be revised in the future. Adverse events of vaccine administration, such as vaccine-induced immune thrombotic thrombocytopenia (VITT), have so far been hidden by the media due to biased propaganda. The institute finds many cases in which this cause is recognized. These situations have come in waves; however, they have not yet been resolved despite measures put in place to screen for heparin-induced thrombocytopenia (HIT) antibodies in patients admitted for surgery. Four positive cases of HIT antibodies have been confirmed at the institute since the start of vaccination; this frequency of positive cases for HIT antibodies has rarely been observed before. Fatal cases due to VITT have also been reported following the administration of COVID-19 vaccines. [ Se han confirmado cuatro casos positivos de anticuerpos HIT en el instituto desde el inicio de la vacunación; esta frecuencia de casos positivos para anticuerpos HIT rara vez se ha observado antes. También se han informado casos fatales debido a VITT después de la administración de vacunas COVID-19 [ Se han confirmado cuatro casos positivos de anticuerpos HIT en el instituto desde el inicio de la vacunación; esta frecuencia de casos positivos para anticuerpos HIT rara vez se ha observado antes. También se han informado casos fatales debido a VITT después de la administración de vacunas COVID-19 [15 ].
As a safety measure, additional booster shots should be discontinued. Also, The date of vaccination and the time elapsed since the last vaccination should be recorded in the clinical history of the patients. Due to the lack of awareness of this group of diseases among doctors and the general public in Japan, a history of vaccination against COVID-19 is often not documented, as in the case of influenza vaccination. Time since last COVID-19 vaccination may need to be considered when invasive procedures are required. Various practical measures have been reported that can be implemented to prevent a decline in immunity [ 16]. These include limiting the use of nonsteroidal anti-inflammatory drugs, including paracetamolto maintain low body temperature, appropriate use of antibiotics, smoking cessation, stress management, and limiting the use of lipid emulsions, including propofol, which can cause perioperative immunosuppression. [ 17 ].
To date, when comparing the advantages and disadvantages of mRNA vaccines, vaccination has been commonly recommended. As the COVID-19 pandemic becomes better controlled, the fallout from the vaccine is likely to become more apparent. It has been hypothesized that there will be an increase in cardiovascular diseases, especially acute coronary syndromes, caused by spike proteins in genetic vaccines [ 18 , 19]. In addition to the risk of infections due to decreased immune functions, there is a possible risk of unknown organ damage caused by the vaccine that has remained hidden without apparent clinical manifestations, mainly in the circulatory system. Therefore, careful risk assessments before surgery and invasive medical procedures are essential. More randomized controlled trials are needed to confirm these clinical observations.
In conclusion, vaccination against COVID-19 is an important risk factor for infections in critically ill patients.«
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