Dr. Maria Tulpan, endocrinologist: In regards to the levels of reproductive life and their reference to metabolism

Within the webinar devoted to “Menopause: interdisciplinary views” dr. Maria Tulip sort out the complicated topic of the levels of a lady’s reproductive life and their impact on metabolism.

With intensive expertise in endocrinology, Dr.

Menopause and its long-term results

“Menopause represents ovarian sensitisation. We’re born with about one million follicles, throughout our life we ​​lose them in a short time. Once we are at menarche, the lady has virtually 300,000 follicles. Across the age of 40, we imagine {that a} girl’s fertility decreases considerably till, at menopause, there are about 1000 follicles left,” defined Dr. Tulpan. She identified that hormonal adjustments start lengthy earlier than menopause formally, typically 5 to 10 years earlier, making correct analysis of peri-menopause tough.

The long-term penalties of menopause are vital, together with an elevated danger of heart problems and metabolic syndrome. Dr. Tulpan stated that “heart problems is the primary consequence to seem across the age of 55. Girls have the next danger of creating heart problems after menopause in comparison with males, in distinction to the scenario earlier than menopause. “

Advantages and Dangers of Hormone Substitute Remedy (HRT)

One other main matter lined was hormone substitute remedy (HRT). “The advantages of HRT are evident within the first 10 years after menopause,” defined Dr. Tulpan. She defined the advantages of HRT in stopping heart problems and osteoporosis, whereas additionally mentioning related dangers reminiscent of an elevated danger of breast most cancers and thrombosis.

“The danger of breast most cancers will increase to 19/1000 girls underneath mixed hormonal remedy, in comparison with 15/1000 in girls with out hormonal remedy”, with a relative danger of 1.26, thought of a really low danger. The largest danger itself is the postmenopausal interval“stated Dr. Tulpan, saying that “hysterectomized girls who obtained estrogen-only remedy have a decrease danger of breast most cancers.”

Various remedy and the significance of life-style

For girls unable or unwilling to take HRT, Dr. Tulpan mentioned non-hormonal remedy choices and the significance of a wholesome life-style. “Weight loss program and bodily exercise should be a part of our suggestions,” she stated, emphasizing the essential position of train and satisfactory protein consumption in sustaining muscle mass and bone density. these are supplemented with dietary supplements which have been specifically developed to compensate for the adjustments within the physique of girls who’ve reached menopause.

Amongst options to HRT for vasomotor signs, Dr. Tulpan talked about using phytoestrogens and low-dose antidepressants, in addition to newly accredited therapies reminiscent of neurokinin receptor antagonists. “There are different choices we will provide girls who don’t need or cannot undergo hormone remedy,” she stated.

Conclusions and suggestions

In conclusion, Dr. Tulpan reiterated the necessity for a personalised strategy within the remedy of menopausal girls. “Remedy should be individualized for every affected person. We have to get a full historical past in order that we will discover out if the affected person will profit or if he’s at larger danger,” she stated. He additionally emphasised the significance of normal follow-up of sufferers on re-treatment. hormone substitute to evaluate dangers and advantages alongside the way in which.

Dr. Maria Tulpan’s intervention offers useful perception into menopause and menopause administration, highlighting the necessity for satisfactory data and personalised medical care to make sure girls’s long-term well-being, excerpted from the webinar . “Menopause: interdisciplinary views“.

The webinar was organized by Individuals and Firms sponsored by the associateVitavea RomaniaviaManhae – the model professional in girls’s well being and sweetness from the French groupHaveathe biggest European producer of meals merchandise and promoted with the assistance of platforms  EventsMax.roand Medical Supervisor.ro.