“Dr. Anan” reveals the mutated virus Change yourself without focusing on escaping the landscape. But focusing on the ability to bind the ACE2 receptor protein on the cell surface is scarier than the kind of good escape.
Dr. Anant Chongkaewwatana Director of the Animal Health Innovation and Management Research Group The National Center for Genetic Engineering and Biotechnology (Biotech) has released a Facebook page. Anan Jongkaewwattana about a mutant virus that changes itself Until it spreads faster, stating so
SARS-CoV-2 virus escaping immunity is a change in one’s appearance. until the antibodies in our body remember the old virus I can’t remember the new one it facilitates the entry of the virus into the body This is simple.
Problems with questions Of a virus changing itself in a way that doesn’t focus on escaping the landscape but focused on being able to bind ACE2 receptor proteins well on the cell surface. How will the virus affect it? Because if the antibody binds even if it binds the receptor protein well they have no chance to reach that cell anyway
Like the case of BA.2.75 that I talked about yesterday in Oxford research The virus chooses to make itself more tightly attached to the cell (9 times than the original BA.2) instead of making itself capable of escaping the immune system.
answer to this question Explained by an article published in npj vaccines journal several months ago.
Imagine the mechanism of action of an antibody in our body: binding to the spike protein of the virus in the same position as the spike binding to the receptor protein.
Normally, nature produces antibodies. to grip specific spikes and much tighter than the receptor protein But if the spike tip changes itself It binds to the receptor protein many times more tightly, perhaps even stronger than the antibody’s ability to bind to the spike tip.
along with the Spike change to some extent reducing the binding properties of antibodies which were previously very specific and tightly packed.
This will be an important factor for the virus to infect cells more easily. Although our body has some antibodies that can catch the virus. (The virus does not escape the landscape.)
According to this idea, if the virus transforms to become increasingly bound to the receptor protein to such a degree that the antibody is indeed overwhelmed, how many antibodies are there? From vaccination or infection, it may not be useful.
But the information at this time we are not yet at that point. And that’s why scientists would be more interested in this type of self-changing virus than escaping antibodies.
due to the latter Our body produces new antibodies. specific to which the resulting changes can be managed. But first it has to make a more tightly bound antibody, which is much more difficult.
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