Gonadotropin-releasing hormone (GnRH, gonadotropin-releasing hormone), a sex hormone that stimulates the gonads, can unexpectedly cause a’diabetic foot ulcer’, a representative complication of diabetes, according to research results. Diabetic foot disease is a typical complication of diabetes, and even a small wound on the foot does not heal and worsens into an ulcer, and in severe cases, the toe is amputated.
Ajou University Hospital’s Otorhinolaryngology Department Professor Kim Cheol-ho team (Lee Yoon-sang, Kang Sung-woon) and Orthopedic Surgery Professor Young-wook Park, the sex hormone GnRH, wounded a diabetic mouse to see how it affects diabetic foot ulcers. When two or more drugs are used together, one drug decreases the effect of the other drug, or a drug that decreases the effect of both drugs on the wound site was examined to see how GnRH affects the healing of diabetic wounds. By confirming that the GnRH receptor was expressed in neutrophils (cells involved in innate immunity) of the neutrophils, it was confirmed that neutrophils can respond to GnRH. It was revealed on the 28th that it was confirmed through (in vitro). In addition, it was confirmed through several experiments that the induction of NETosis was suppressed when GnRH antagoinst was treated with GnRH.
Neutrophils are one of the innate immune cells that respond first at the forefront during pathogen infection, and are common enough to account for 50-70% of white blood cells in the blood. Therefore, the promotion of NETosis, which is the death of neutrophils, is believed to be one of the main causes of diabetic foot ulcers.
The research team explained that GnRH can be the cause of diabetic foot ulcers, which is a representative complication of diabetes, and by controlling this, the possibility of overcoming diabetic foot ulcers caused by poor wound healing was confirmed. GnRH is a hormone secreted from the anterior pituitary gland. It is a hormone that stimulates the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and the relationship with diabetes is hardly known. Professor Kim Cheol-ho said, “In order to promote wound healing in diabetic foot ulcers, epithelial cell growth factors or hyperbaric oxygen therapy have been used to help tissue regeneration.” It is meaningful that it presented the possibility of a new treatment that can quickly cure.
The results of this study were published in the latest issue of’GnRH impairs diabetic wound healing through enhanced NETosis’ in the international academic journal Cellular & Molecular Immunology (IF:8.48) in the field of biology. done.
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