Covid: autologous stem cells repair lung injuries – Medicine

The administration of autologous stem cells (stem cell autotransplantation) to a patient with severe clinical form of bilateral SARS-CoV2 interstitial pneumonia, before hospital admission, and repeatedly in the four weeks following his discharge from the hospital, contributed to to determine not only a quick negativization of the molecular swab examination, but also a total regression of the bilateral lung lesions just 40 days after the onset of the disease.

The case is told in a rationale published in the scientific journal Applied Sciences, first author the president of the Scientific Society Sis 118 Mario Balzanelli. The results of this case report will soon be presented to the international scientific community.

Stem cell autotransplantation was carried out in Italy for the first time in a First Intervention Point of SET 118.

“In this perspective, we believe that plasma can act as a formidable additional weapon to be used in the integrated strategy to combat both COVID-19, especially if in a severe clinical phase, and post-COVID (or Long Covid) syndrome, particularly at in order to completely avoid or reduce the residual pulmonary fibrosis as much as possible, and therefore the very heavy permanent organ damage which tends to result, with variable appearance over time, in chronic respiratory failure “, explained to ANSA Balzanelli. “We are not referring, in this case, to heterologous plasma, that is to plasma donated by another subject – he added – the answer, however, immediately available and at no cost, is given by autologous plasma, ie the plasma of the same subject that becomes need to treat in emergency for a severe clinical form of COVID-19 “. Basically, the plasma, in this case, is not used as a vehicle for antibodies to SARS-CoV2, as already happens in the logic of administration of heterologous plasma, but as a ‘therapeutic’ vehicle for autologous stem cells, i.e. belonging to the same sick subject. . (HANDLE).

“Our plasma – continued Balzanelli – contains hundreds of thousands of ‘dormant’ stem cells which, following activation in a very short time with specific molecules, a process that is carried out, following blood sampling, outside the organism, are activated, awakened and, once re-injected under the skin in the subject from which they come, immediately implement, managed by the neuro-endocrine-immune system of the organism itself, their own therapeutic action “The first author of the study underlined therefore that “SIS 118 raises attention to the possible and decisive therapeutic role of stem cells in the acute management of the critically ill COVID-19 patient, both at the hospital level, in severe clinical forms, and at home, in the oligosymptomatic forms, especially when related to categories of positive subjects at greater risk, such as the elderly “.

And he concluded: “Stem cells, moreover contained in children to a much higher extent than adults, which is why we believe children are considerably more protected than adults from the more serious consequences of COVID-19 (MG Balzanelli et al: Mesenchymal Stem Cells: The Secret Children’s Weapons against the SARS-CoV-2 Lethal Infection, Appl. Sci 2021, 11, 1696.https: //doi.org/10.3390/app11041696), represent – in our opinion – revolutionary weapons capable of effectively counteract the systemic immune-inflammatory cascade that characterizes the most severe clinical forms of COVID-19, to modulate it in an anti-inflammatory sense as well as to directly activate and regulate the “massive” repair of cells, tissues, damaged organs between which, in the first place, the lung “. (HANDLE).

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