Covid and vaccines: the side effects of mRna vaccines (Pfizer and Modern) and viral vector (AstraZeneca e Johnson & Johnson). All the details published on the Aifa (Italian Medicines Agency) website
The European Medicines Agency and AIFA have so far authorized two COVID-19 vaccines a viral vector. A viral vector vaccine uses a virus (usually an incompetent adenovirus for replication) to carry the sequence of the genetic code that codes for the protein into the cell spike. The immune system activates against the protein and produces antibodies which, if the subject comes into contact with the virus, will protect him from infection. The viral vector vaccines authorized by EMA and AIFA are Vaccino Vaxzevria and COVID-19 Vaccine Janssen (Johnson & Johnson).
All information is available on This Page de site Aifa.
Possible side effects of the Vaxzevria vaccine (from the Brochure)
Like all medicines, this vaccine can cause side effects, although not everybody gets them. If you notice any side effects not mentioned in this leaflet, please tell your doctor, pharmacist or nurse.
Get urgent medical attention if symptoms of a severe allergic reaction occur. Such reactions can include a combination of any of the following symptoms:
– feeling faint or lightheaded
– changes in heartbeat
– shortness of breath
– wheezing
– swelling of the lips, face or throat
– hives or rash
– nausea o vomito
– stomach ache.
The following side effects may occur with Vaxzevria:
Very common (may affect more than 1 in 10 people)
– tenderness, pain, warmth, itching or bruising where the injection is given
– feeling tired (fatigue) or generally feeling unwell
– chills or a feeling of fever
– headache
– feeling sick (nausea)
– joint pain or muscle pain
Common (may affect up to 1 in 10 people)
– swelling or redness where the injection is given
– fever (> 38 ° C)
– being sick (vomiting) or diarrhea
– low levels of platelets in the blood
Uncommon (may affect up to 1 in 100 people)
– sleepiness or dizziness
– decreased appetite
– enlarged lymph nodes
– excessive sweating, itching or rash
Very rare (may affect up to 1 in 10,000 people)
– blood clots often in unusual sites (e.g. brain, intestines, liver, spleen) associated with low
blood platelet levels
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly.
The most frequently observed adverse reactions during the current vaccination campaign are fever, headache, muscle or joint pain. These are non-serious reactions, of mild or moderate severity which, although annoying, resolve in a few hours or days, often without even resorting to symptomatic treatments (painkiller or similar).
As with all drugs, allergic reactions up to anaphylactic shock are also possible, albeit very rare. For this reason, vaccinations are performed in safe contexts by trained personnel and there is an observation period of at least 15 minutes after vaccination. Another aspect that is taken into account is that, following the injection, anxious reactions can also occur with vaso-vagal phenomena ranging from the sensation of being about to faint up to actual fainting, for which the staff pays be careful to avoid falling injuries.
Monitoring for adverse reactions is described in the monthly surveillance reports available who.
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Possible side effects of the vaccine Janssen – Johnson & Johnson (dal Brochure)
Like all vaccines, COVID-19 Vaccine Janssen can cause side effects, although not everybody gets them. Most of the side effects occurred within 1-2 days of vaccination.
Get urgent medical attention if you experience symptoms of a severe allergic reaction. These reactions may include a combination of some of the following symptoms:
- * feeling faint or light-headed
- * changes in heartbeat
- * shortness of breath
- * wheezing
- * swelling of the lips, face or throat
- * hives or rash
- * nausea o vomito
- * stomach ache.
The following side effects may occur with this vaccine.
Very common: may affect more than 1 in 10 people
- * headache
- * nausea
- * muscle aches
- * pain where the injection is given
- * feeling of extreme tiredness
Common: may affect up to 1 in 10 people
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- * redness where the injection is given
- * swelling where the injection is given
- * chills
- * articolar pains
- * temperature
- * cough
Uncommon: may affect up to 1 in 100 people
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- * rash
- * muscle weakness
- * pain in the arms or legs
- feeling of weakness
- * feeling of general malaise
- * aged
- * sore throat
- * back pain
- * tremor
- * excessive sweating
Rare: may affect up to 1 in 1,000 people
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- * allergic reaction
- * urticaria
Not known (frequency cannot be estimated from the available data)
- * severe allergic reaction
MRNA VACCINES (PFIZER AND MODERN)
The European Medicines Agency and AIFA have authorized two COVID-19 vaccines: Pfizer mRNABNT162b2 (Comirnaty) e COVID-19 Vaccine Moderna mRNA -1273.
The most frequently observed adverse reactions (more than 1 in 10 people) in the COVID-19 mRNA BNT162b2 (Comirnaty) vaccine study were generally mild or moderate in severity and resolved within days of vaccination. These included pain and swelling at the injection site, fatigue, headache, pain in the muscles and joints, chills and fever. Injection site redness and nausea occurred in less than 1 in 10 people. Injection site itching, pain in limbs, swollen lymph nodes, difficulty falling asleep and feeling sick were uncommon, affecting fewer than 1 in 100 people. Weakness in the muscles of one side of the face (acute peripheral facial paralysis) occurs rarely, in less than 1 in 1000 people.
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The most frequently observed adverse reactions during the current vaccination campaign are fever, headache, muscle or joint pain, injection site reactions and fatigue. These are non-serious reactions, of mild or moderate severity which, although annoying, resolve in a few hours or days, often without even resorting to symptomatic treatments (painkiller or similar).
As with all drugs, allergic reactions up to anaphylactic shock are also possible, albeit very rare. For this reason, vaccinations are performed in safe contexts by trained personnel and there is an observation period of at least 15 minutes after vaccination. Another aspect that is taken into account is that, following the injection, anxious reactions can also occur with vaso-vagal phenomena ranging from the sensation of being about to faint up to actual fainting, for which the staff pays be careful to avoid falling injuries.
Monitoring for adverse reactions is described in the monthly surveillance reports available who.
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