[메디컬투데이=최재백 기자] It has been confirmed that pure flavonoids can stop the breakdown of vitamin B6 within the mind.
Analysis outcomes exhibiting that pure flavonoids can stop the breakdown of vitamin B6 within the mind have been printed in ‘eLife’.
Vitamin B6 stimulates the synthesis of serotonin, dopamine, and gamma-aminobutyric acid and has the impact of decreasing homocysteine ranges within the blood. In different phrases, sustaining enough ranges of B nutritional vitamins, particularly vitamin B6, is vital for correct neurotransmitter synthesis and homocysteine metabolism, and has a direct impact on cognitive operate.
Based on consultants, vitamin B6 deficiency shouldn’t be solely associated to the work of the hippocampus space, which is especially concerned in reminiscence consolidation and studying, however it is usually associated to ‘consciousness’, a characteristic of psychological well being .
Conflicting analysis outcomes have been produced concerning the impact of taking vitamin B6 dietary supplements to deal with vitamin B6 deficiency on cognitive operate.
Due to this fact, the analysis group lately found that when vitamin B6 dietary supplements are mixed with 7,8-dihydroxyflavone, a pure flavonoid, the flavonoid produces ‘pyridoxal phosphatase (PDXP)’, which breaks down vitamin B6 preserves ranges of vitamin B6 within the mind by instantly inhibiting enzymes.
The analysis group famous that PDXP enzyme exercise was improved within the hippocampus of outdated mice in comparison with younger mice, and defined that when vitamin B6 dietary supplements are used alone, the therapeutic impact shouldn’t be enough as a result of Vitamin B6 is instantly damaged down by the motion of PDXP.
Along with earlier analysis exhibiting that mice with PDXP that was suppressed by genetic manipulation had higher spatial studying and reminiscence means than mice with regular PDXP, they evaluated the cognitive operate of mice utilizing Barnes maze on this research.
The Barnes maze is a device to evaluate hippocampus-dependent spatial reminiscence, which includes studying and remembering the placement of a hidden gap from a sequence of visible cues. The Barnes Maze was uncomfortably brightly lit and designed in order that only some of the numerous escape holes may very well be used.
The researchers stated that PDXP-knockout mice have been higher at studying the place the escape gap is utilizing visible cues (shapes, patterns and colours) across the platform. Subsequently, they defined that they used small molecule screening, protein crystallography, and double-layer interferometry to verify that 7,8-dihydroxyflavone has a direct impact on PDXP operate.
They concluded that combining pure flavonoids, resembling 7,8-dihydroxyflavone, or PDXP inhibitors, with vitamin B6 dietary supplements can successfully enhance mobile vitamin B6 ranges by stopping breakdown vitamin B6.
In response to issues about whether or not animal take a look at outcomes could be utilized on to people, consultants defined that vitamin B6 neurotransmitter synthesis and homocysteine metabolismcould be mechanically exchanged between mice and people.
The analysis group stated that the purpose of future analysis is to analyze how, if vitamin B6 ranges enhance by blocking PDXP with 7,8-dihydroxyflavone, this results in higher cognitive operate.
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2024-07-04 01:08:41
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