Delivery time2024-02-13 05:00
Chinese research team: “Possibility of use in screening and early intervention for high-risk groups for dementia”
(Seoul = Yonhap News) Reporter Jooyoung Lee = Four plasma proteins that can be used to predict the risk of developing all-cause dementia (ACD), Alzheimer’s disease (AD), and vascular dementia (VaD) 10 years before diagnosis have been discovered. .
dementia
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On the 13th, in the scientific journal Nature Aging, Dr. Yu Jintai’s team at Fudan University and Shanghai Medical School in China analyzed the relationship between plasma proteins and the onset of dementia in over 52,000 adults registered with the UK Biobank, and identified them as predictors of long-term dementia risk. They announced that they had identified four proteins that could be utilized.
Previous studies have also investigated plasma proteins as biomarkers for predicting long-term dementia risk in healthy adults, but most have focused on one or a few proteins or lack large-scale data such as the UK Biobank.
The research team also pointed out that previous studies had neglected how these proteins could predict the onset of all-cause dementia, Alzheimer’s disease, and vascular dementia over a long period of time, up to 10 years.
The research team identified plasma biomarkers related to dementia prediction in data from 52,645 dementia-free participants (median age 58 years) registered in the UK Biobank, and found that each biomarker was associated with ACD and AD over the next 14.1 years (median). , we investigated how well it predicts the onset of VaD.
A total of 1,417 people were diagnosed with dementia during the follow-up period. 833 people, including 219 who developed the disease within 5 years, were diagnosed with dementia within 10 years of starting the study, and 584 people developed the disease after 10 years.
The research team found that among the 1,463 plasma proteins included in the analysis, four proteins were consistently associated with the development of all-cause dementia, Alzheimer’s disease, and vascular dementia.
The four plasma proteins are glial fibrillary acidic protein (GFAP), neurofilament light chain (NEFL), growth differentiation factor 15 (GDF15), and latent transforming growth factor beta binding protein 2 (LTBP2).
Based on this, a 10-year prediction model for ACD, AD, and VaD was created, and as a result, all four proteins showed high predictive value, and in particular, GFAP, which has previously been attracting attention as a dementia-related factor, was found to have the strongest correlation with dementia. .
People with high GFAP levels were 2.32 times more likely to develop dementia than those without it. In particular, GFAP and LTBP2 had very high dementia prediction specificity, and GFAP and NEFL were found to start changing at least 10 years before dementia was diagnosed. .
The research team said that this shows that GFAP has the potential to be a potential biomarker for early assessment of the risk of all-cause dementia, Alzheimer’s disease, and vascular dementia, and that the results of this study provide important implications for screening and early intervention in high-risk groups for dementia.
◆ 출처 : Nature Aging, Jian-Feng Feng et al., ‘Plasma proteomic profiles predict future dementia in healthy adults’,
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