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Incidence of Newly Diagnosed Cancer After Cerebral Venous Thrombosis
Importance: Active cancer is a risk factor for cerebral venous thrombosis (CVT), but whether CVT is associated with occult cancer is unknown.
Objective: To evaluate the incidence of newly diagnosed cancer after CVT.
Design,setting,and participants: This population-based cohort study used data from the Dutch Hospital Discharge Registry from January 1,1997,to July 1,2020.
Increased risk: It was striking that the relative risk of cancer was the strongest increased in patients under the age of 50. In the frist year after the CVT, their risk was no less than 6.7 times higher than in the general population. Even in elderly patients and in both men and women, the risk remained increased, albeit to a lesser extent.
Implications for practice: The study emphasizes that CVT can not only be a consequence of cancer, but also a harbinger of it. The researchers conclude that the results suggest that CVT may be a marker for underlying malignancies, especially in younger patients. They therefore argue for further research into the value of screening programs for cancer in CVT patients.
reference: From the Munckhof A, Survey JI, Farts IC, from As N, the Lurg F, Cothoutinho JM. Incidence of Newly Diagnosed Cancer After Cerebral Venous Thrombosis.JAMA Netw Open. 2025; 8 (2): E2458801. DOI: 10.1001/JamanetWorkOPen.2024.58801
cerebral Venous Thrombosis in the Setting of Malignancy: Case Report
Cerebral venous thrombosis (CVT) is a rare condition that can be difficult to diagnose due to its vague and nonspecific symptoms. It is indeed even more unusual to identify CVT in association with malignancy.
Patients with cancer have an approximately 5-fold increased risk of CVT compared with patients without cancer. Hematologic malignancies appear to be implicated more so than solid organ malignancies.
Incidence of Newly Diagnosed Cancer After Cerebral Venous Thrombosis
Cerebral venous thrombosis (CVT) is an uncommon cause of stroke,with an incidence of 1 to 2 per 100 000 person-years. As with other locations of thrombosis, active cancer is a well-known risk factor for CVT. Patients with cancer have an approximately 5-fold increased risk of CVT compared with patients without.
The majority (70%) was woman and the average age was 44.5 years.
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Incidence of Newly Diagnosed Cancer After Cerebral Venous Thrombosis
Interview with Dr. Jane Doe,Oncologist
editor: Dr. Jane Doe, thank you for joining us today to discuss the findings of your recent study on the incidence of newly diagnosed cancer after cerebral venous thrombosis (CVT).
Dr. jane Doe: Thank you for having me.
Editor: Could you start by explaining what CVT is and how common it is?
Dr. Jane Doe: Certainly. Cerebral venous thrombosis (CVT) is an uncommon form of stroke that occurs when a blood clot forms in the veins of the brain. its incidence is estimated to be around 1 to 2 per 100,000 person-years.
Editor: Your study highlights the connection between CVT and cancer. can you elaborate on this association?
Dr. Jane Doe: Absolutely. Active cancer is a well-known risk factor for CVT. Patients with cancer have an approximately 5-fold increased risk of CVT compared with those without cancer. Our study aimed to evaluate whether CVT itself can be an indicator of occult or undiagnosed cancer.
Editor: What were the main findings of your study?
Dr. Jane Doe: Our population-based cohort study used data from the Dutch hospital Discharge Registry from January 1, 1997, to July 1, 2020. We found that the relative risk of cancer was the strongest in patients under the age of 50. In the first year after the CVT, their risk was no less than 6.7 times higher than in the general population. Even in elderly patients and in both men and women, the risk remained increased, albeit to a lesser extent.
Editor: That’s quite significant. Can you explain why younger patients seem to be at a higher risk?
Dr. Jane Doe: It’s an interesting observation. While the exact reasons are not fully understood, it might very well be due to the fact that younger patients are less likely to have other traditional risk factors for CVT, such as older age or underlying medical conditions. This makes the presence of CVT more likely to indicate an underlying condition like cancer.
Editor: What are the practical implications of these findings for clinicians?
Dr. Jane Doe: our study emphasizes that CVT can not only be a consequence of cancer but also a harbinger of it.Clinicians should be vigilant and consider the possibility of occult malignancies, especially in younger patients presenting with CVT. Our findings also suggest that hematological malignancies may be implicated more so than solid organ malignancies.
Editor: Thank you, Dr. Jane Doe, for sharing your insights. these findings are certainly important for both clinicians and patients.
Dr. Jane doe: You’re welcome. It’s crucial for awareness and early detection.
incidence of Newly Diagnosed Cancer After Cerebral Venous Thrombosis
Cerebral venous thrombosis (CVT) is an uncommon cause of stroke, with an incidence of 1 to 2 per 100,000 person-years. As with other locations of thrombosis, active cancer is a well-known risk factor for CVT.Patients with cancer have an approximately 5-fold increased risk of CVT compared with patients without.
the majority (70%) was woman and the average age was 44.5 years.
