High iron levels, low glucose and uric acid levels
Entered 2024.02.10 14:00 Entered 2024.02.10 14:00 Modified 2024.02.10 12:13 Views 12,658
People who celebrated their 100th birthday tended to have lower glucose, creatinine, and uric acid levels after their 60s. [사진=게티이미지뱅크]The era of living to 100 years is no longer a dream but a reality. In fact, the number of centenarians worldwide has approximately doubled every decade since the 1970s.
Efforts to find the secret to longevity are continuing. Research is continuing in various fields, including genetic factors as well as lifestyle factors.
A study published in the aging journal GeroScience revealed several common biomarkers, including cholesterol and glucose levels, in people living over 90 years of age.
Researchers analyzed data from 44,000 Swedes aged 64 to 99 who underwent health assessments. Subjects were followed through Swedish registry data for up to 35 years. Of these, 1,224 (2.7%) lived to the age of 100. The majority (85%) of centenarians were women. The researchers compared the biomarker profiles of people who lived longer than 100 years and those who lived a short life, and examined the association between the profiles and the likelihood of becoming a centenarian.
It included 12 blood-based biomarkers related to inflammation, metabolism, liver and kidney function, as well as potential malnutrition and anemia. The biomarker related to inflammation was uric acid, a waste product in the body that arises from digestion of certain foods. In addition, markers related to metabolic status and function, including total cholesterol and glucose, and liver function and liver function, such as alanine aminotransferase (Alat), aspartate aminotransferase (Asat), albumin, gamma-glutamyl transferase (GGT), and alkaline phosphatase. Related markers were investigated. We also looked at creatinine, which is related to kidney function, and iron and total iron binding capacity (TIBC), which are related to anemia. Albumin, a nutrition-related biomarker, was also investigated.
The results of the study showed that overall, people who celebrated their 100th birthday tended to have lower glucose, creatinine, and uric acid levels after their 60s. Median values for most biomarkers were not significantly different between centenarians and centenarians, but centenarians rarely showed extremely high or low values. For example, few centenarians had blood sugar levels above 6.5 or creatinine levels above 125 early in life.
For many biomarkers, both centenarians and centenarians had values outside the range considered normal in clinical guidelines. The researchers speculated that this may be because these guidelines were established based on a younger, healthier population.
When examining which biomarkers were associated with the likelihood of reaching 100 years of age, it was found that all but two of the 12 biomarkers (alat and albumin) were associated with the likelihood of reaching 100 years of age.
People with lower total cholesterol and iron levels were less likely to reach age 100 than those with higher levels. People with high levels of glucose, creatinine, uric acid, and liver function indicators also had a reduced probability of becoming centenarians.
In absolute terms, the differences were somewhat smaller for some biomarkers, whereas the differences were somewhat larger for other biomarkers. For example, in the case of uric acid, the absolute difference was 2.5 percentage points. That is, the group with the lowest uric acid levels had a 4% chance of reaching 100 years of age, while the group with the highest uric acid levels had only a 1.5% chance of reaching 100 years of age. “It is reasonable to think that factors such as nutrition and alcohol consumption play a role,” the researchers said. “It is probably not a bad idea to track kidney and liver levels, glucose and uric acid levels as one ages.”
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2024-02-11 16:16:17
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