“Cancer Vaccine: Treatment of Pancreatic Cancer with mRNA Technology”

Pancreatic cancer is one of the deadliest cancers,german medicinefactoryThere is latest research，The use of mRNA technology can be used to customize vaccines for pancreatic cancer patients, bringing hope for future treatment and prevention of cancer. The research has been published in the medical journal “Nature”.

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According to comprehensive foreign media reports, the pharmaceutical company that developed the new crown vaccine FubitaiBioNTechconducting a clinical study on pancreatic cancer,Sixteen patients with early-stage pancreatic cancer were recruited. After undergoing tumor removal surgery, tumor samples were taken out for analysis. The researchers compared the normal cell gene sequence of the patient, found the mutation and made an mRNA vaccine, and then re-injected it into the patient. During this period, 8 injections were required, and the vaccine was injected into the blood.

The results show，The vaccine successfully produced an effective and long-lasting immune response in 8 of them, and the cancer did not recur within 18 months after the operation, indicating that the immune system of half of the tested patients learned how to recognize and repel cancer cells.The results show more, one of the patients showed signs of cancer cell metastasis to the liver during the operation, and the cancer cells in the liver were completely eliminated after receiving the vaccine. However, the other half of the patients showed signs of recurrence within 13 months after the operation.

check information，Generally, pancreatic cancer will recur within 13 months after surgery, because pancreatic cancer is a cancer that is more likely to recur. Even after surgery, it is difficult to completely remove cancer cells.

Vaccines tailored for pancreatic cancer patients

Benjamin Greenbaum, author of the paper and scientist at Memorial Sloan Kettering Cancer Center (MSK), said,

“About 5 to 10 years ago, pancreatic cancer was considered a difficult disease to cure, but now it is not impossible. We may now be able to successfully cure pancreatic cancer through vaccination.”

Studies have pointed out that the principle of the vaccine is to find out the mutation between tumors and normal cells to make a vaccine. Like the new crown vaccine, it “trains” human immune cells to deal with mutant cells and strengthens the ability of immune cells to help eliminate cancer cells. Benjamin Greenbaum continued to point out that because each person’s cancer cells mutate differently, the vaccine needs to be customized. In the preliminary stage, under the premise that the vaccine cannot be mass-produced, it is estimated that the single dose of the vaccine will cost US$100,000 (about HK$780,000). “This is a personalized vaccine, which is produced according to the specific mutations of the patient’s tumor. New proteins are produced in the tumor, and the immune system may recognize these proteins.”

Although the scale of the clinical trials is small, it still needs to be proved by large-scale experiments, but some experts pointed out that the research results are encouraging.Ira Mellman, director of cancer immunology research at biotech company GenentechThere is hope for a “cancer vaccine”seefrankly brought a new dawn in the treatment of cancer: “We have experienced 30 years of failure in the past, and now is a good start.”

7 common symptoms of pancreatic cancershape

Pancreatic cancer is the fourth most deadly cancer in Hong Kong, causing 813 deaths in 2020. Because its symptoms are not obvious, it is not easy to detect in the early stage, and the cure rate is quite low, so it is also known as the “King of Cancer”.According to the Hong Kong Cancer Foundation, the seven common symptoms of pancreatic cancer are as follows：

pancreatic cancer10big risk factor

According to the Hong Kong Hospital Authority, pancreatic cancer is a highly invasive cancer. Because the malignant tumor in the pancreas grows slowly and its location is hidden, the initial symptoms are not obvious. Pancreatic cancer was detected in the test, so many patients did not realize the disease until the advanced stage of cancer, thus delaying treatment and affecting the survival rate.

Even if it can be surgically removed, the patient’s survival time is shorter than that of other cancer patients. Most pancreatic cancers occur in people over the age of 65. Other risk factors include:

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