| ▲ Research results have shown that combining computer-based cognitive rehabilitation therapy with non-invasive transcranial electrical stimulation therapy helps slow cognitive decline in elderly people at risk for severe dementia. mind (Image = DB) |
[메디컬투데이=최재백 기자] Research has shown that combining computer-based cognitive rehabilitation (CR) treatment with non-invasive transcranial direct current stimulation (tDCS) treatment can help slow cognitive decline in older people who are at high risk for Depression.
Research results published in ‘JAMA Psychiatry’ show that combining computer-based cognitive rehabilitation treatment with non-invasive transcranial direct current electrical stimulation (tDCS) treatment can help slow cognitive decline in the elderly at high risk for depression.
Major depressive disorder (rMDD) in remission and cognitive impairment (MCI) are both mental illnesses that increase the risk of depression.
Slowing the rate of cognitive decline is very important for maintaining independent living skills and preventing dementia in older people. Therefore, the research team at the Center for Addiction and Mental Health concluded that a combined treatment that combines computer memory training and thinking skills and non-invasive light electrical stimulation therapy can reduce cognitive decline in high-risk elderly people. for depression, especially those with rMDD. They said there could be a delay.
The research team evaluated the effects of CR treatment and tDCS treatment on cognitive decline in 375 older adults with an average age of 72 years and a history of rMDD, MCI, or both.
Patients received sham treatment as a control group or a combination treatment combining CR treatment and non-invasive tDCS treatment as an experimental group. Computer memory and thinking skills training, or cognitive rehabilitation (CR) therapy, literally involves training to improve memory and thinking skills using a computer.
The research team put 6 to 8 patients together in one group in a school classroom-like environment and performed CR treatment 5 times a week for 8 weeks under the supervision of one or two coaches per group. After that, in order to obtain an increased effect, CR treatment was performed once every 6 months, 5 times a week, until the study ended, the patient stopped the study, or cognitive function progressed from normal to MCI or MCI to dementia. Between booster treatments, patients were individually asked to participate in online training at home for 20 to 40 minutes per day.
Meanwhile, mild non-invasive electrical stimulation therapy, or tDCS, is a treatment that enhances brain plasticity by delivering a current of 2 milliamps (mAmp) to the frontal lobe area using a portable phone-sized device smart
The research team tried to get the best learning effect from CR treatment by giving an electric current through tDCS treatment for the first 30 minutes while patients were training their thinking skills. They predicted that combined CR-tDCS treatment would produce a synergistic effect and improve brain plasticity more effectively than tDCS treatment alone.
Patient evaluations were performed at the beginning of the study, in the second month of the study, and annually thereafter for 3 to 7 years. As a result of the evaluation, the research team reported that patients who received mixed CR-tDCS treatment experienced slower cognitive decline over an average of four years of follow-up than the control group who received sham treatment.
They found that the benefit of combined treatment was particularly evident in low-risk groups with a low genetic risk for Alzheimer’s disease, and in addition, the effectiveness of combined treatment was better in patients diagnosed with rMDD with or without MCI than in patients diagnosed with MCI. alone
Because patients who are genetically at low risk for Alzheimer’s disease are not usually candidates for intravenous antibody injection treatment, they predicted that a non-invasive combination treatment might be a good option for them.
Experts say that unlike single therapies that work specifically on specific target pathways, combination therapies can delay severe cognitive impairment by more effectively addressing various risk factors such as genes, lifestyle -life, vascular health, and neuroinflammatory factors
They hoped to confirm their findings in a larger study involving diverse populations and further investigate the interaction between the combination treatment and a person’s genetic profile.
Medical Today Reporter Jaebaek Choi ([email protected])
[저작권자ⓒ 메디컬투데이. 무단전재-재배포 금지]
2024-11-18 01:28:00
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– How does the integration of computer-based therapy with transcranial direct current stimulation enhance cognitive recovery in patients?
1. What is the main aim of this research study on cognitive rehabilitation and transcranial electrical stimulation therapy?
2. How does computer-based cognitive rehabilitation therapy work, and how does it help in improving the cognitive function of patients?
3. Can you explain how non-invasive transcranial direct current stimulation therapy works in preventing cognitive decline?
4. What are the potential benefits of combining computer-based cognitive rehabilitation therapy with non-invasive transcranial direct current stimulation therapy for elderly people at high risk for severe dementia?
5. How do you think this combined treatment could potentially impact the quality of life of these patients, especially in terms of maintaining their independent living skills?
6. Are there any concerns or challenges associated with this combined treatment that need to be addressed before it can be widely implemented?
7. In what ways do you think the study’s findings could be applied to a more diverse population, and how might genetic factors play a role in the effectiveness of this treatment?
8. Are there any ongoing or future research initiatives that build upon the results of this study, and what do you believe could be the next step in the development of this treatment approach?
