Traditional cancer treatment methods usually kill cancer cells but also bring huge side effects to the human body. The latest research by a team led by Chun-Wei Chen, a Chinese scientist at the City of Hope Cancer Research Center, found that two cell surface proteins jointly stimulate the growth of cancer cells. If the interaction between them is destroyed, they can Effectively prevents the growth of cancer cells. This breakthrough research and development achievement brings milestone significance to a new treatment method for cancer.
After several years of hard work, a scientific research team led by Chen Junwei, a Chinese associate professor of systems biology at City of Hope, discovered a new cellular mechanism and identified two cell surface proteins, integrins αV and β5, which jointly stimulate the growth of cancer cells. Scientists believe that if they can successfully disrupt the interaction between αV and β5, they can prevent the growth of cancer cells.
In further studies, the scientists determined that a region of integrin αV, called the β-propeller domain, controls the interaction between the two proteins, αV and β5. After achieving a key breakthrough, Chen Junwei’s team conducted a large number of laboratory experiments and computer simulations to create a powerful digital application of CRISPR (an antiviral immune system that exists in bacteria) gene editing technology and discovered the precise targeting of β-propellers. Domains of CpdAV2 as potential cancer drugs.
The scientific research team identified CpdAV2 as a strong candidate compound and applied this compound to human cancer cells in the laboratory, allowing integrins αV and β5 to rapidly separate, destroying the connection between the two proteins, and effectively preventing cancer cells. grow. Chen Junwei said that CpdAV2 compounds are not yet real cancer drugs, and they are still some way away from being the drugs that will eventually hit the market.
Clinically, researchers have found that integrin αV is prominent in multiple cancer types and plays a leading role in cancer progression. The data showed that high levels of integrin αV were also associated with poor prognosis in 3,700 patients with breast, pancreatic, liver, lung, and brain cancers.
By expanding opportunities to develop targeted therapies that sever the link between integrins αV and β5, City of Hope’s breakthrough scientific research will provide effective new approaches to cancer treatment and drug development. Chen Junwei pointed out that this research result reveals a site on the protein with carcinogenic ability that has never been discovered before. This breakthrough opens up a new way for the advancement of tumor therapy and is an important milestone in the City of Hope’s fight against cancer. It will also provide a new way to treat cancer in the future. Drug development has forward-looking significance.
Chen Junwei said that since 2019, more than a dozen team members have been involved in this scientific research work, half of which are Chinese scientists. For more than four years, the main members have been working day and night on research and development, and finally achieved significant gains. This scientific research result was published in the authoritative journal “Nature Structural & Molecular Biology”. Chen Junwei specifically mentioned that the first author of the article, Nicole M. Mattson, has devoted countless efforts and efforts to this end.
Chen Junwei received his bachelor’s and graduate degrees from National Taiwan University, and then received his doctorate in the United States. He currently works at the City of Hope Comprehensive Cancer Center Research Institute. In an exclusive interview with this newspaper, he mentioned that Chinese scientists are playing an increasingly important role in top scientific research results.
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2024-02-25 06:20:00
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