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[1]: Organ-specific biological clocks: Ageotyping for personalized anti… Here, we review data relative to biological aging clocks and omics-based data, suggesting different organ-specific aging rates. Additional research on longitudinal data,including young subjects and analyzing sex-related differences,should be encouraged to apply ageotyping analysis for preventive purposes in clinical practice.
URL: https://pubmed.ncbi.nlm.nih.gov/38447609/
[2]: The IHU HealthAge vision - IHU Healthage – INSPIRE The 5 pillars of the IHU Healthage. Synthesis; Pillar 1: Advancing healthy longevity accessible for all at the national level in France; Pillar 2: Decoding aging thru blood by novel multi-omics function & organ-specific aging clocks and identifying biomarkers and druggable targets on key biological pathways that protect function
URL: https://ihuhealthage.fr/en/visio/
[3]: Metabolomic age (MileAge) predicts health and life span: A … – Science To assess the ability of thes aging clocks to predict age-related morbidity and life span and to capture biological signals beyond those approximated by chronological age , we examined their associations with multiple health and aging markers (e.g., telomere length and frailty) and all-cause mortality. This study presents a comprehensive …
URL: https://www.science.org/doi/10.1126/sciadv.adp3743
Current data from the Inspire-T cohort constitute a major advance to identify markers of aging in good or poor health. This research could thus contribute to the progress of prevention strategies and treatments adapted to each individual.
In addition, the study enabled the creation of a biobank bringing together tissue samples and a database accessible to the scientific community.
Better understanding the mechanisms of aging offers promising perspectives: by adjusting yoru lifestyle or by exploring targeted treatments, it would be possible to slow biological aging and thus promote healthy aging.
Computational and digital analyses in the INSPIRE mouse cohort to define sex-specific functional determinants of biological aging
Yohan Santin, Mattia Chiesa, Amélie Alfonso, Yosra Doghri, Ryeonhi Kang, Fraha Haidar, Pilar Oreja-Fuentes, Occiane Fousset, Rana Zahreddine, Mégane Guardia, Lucas Lemmel, Mara Rigamonti, Giorgio Rosati, Cédrick Florian, Sébastien Gauzin, Sophie Guyonnet, Yves Rolland, Philipe de Souto Barreto, Bruno Vellas, Bruno Guiard, angelo Parini
science Advances, December 2024
Unraveling Biological Aging: New Insights from Organ-Specific Clocks and Multi-Omics
Table of Contents
In recent advances in the field of gerontology, researchers are delving deeper into biological aging, exploring organ-specific clocks and multi-omics to understand aging better and its implications for personalized medicine. We spoke with renowned specialist Dr.Yohan Santin, an expert on the article’s subject matter, to illustrate the latest findings and their potential impact on clinical practice.
Organ-Specific Biological Clocks and Ageotyping
Editor: Can you explain the concept of organ-specific biological clocks and how they differ from more general aging clocks?
Dr.Yohan Santin: Organ-specific biological clocks are physiologic processes that regulate various aspects of cellular and tissue function in a temporally controlled manner. These clocks are crucial in understanding that different organs in the body age at different rates. Our recent research reviews omics-based data suggesting that each organ may have its unique aging rate. This organ-specific aging rate can influence overall health and disease progression, paving the way for personalized anti-aging strategies.
The IHU HealthAge Vision and Decoding Aging
Editor: What specific goals does the IHU HealthAge initiative aim to achieve regarding healthy longevity and aging research?
Dr. Yohan Santin: The IHU healthage initiative focuses on advancing healthy longevity accessible to all at the national level in France. Specifically, it seeks to decode aging through novel multi-omics functions and organ-specific aging clocks. By identifying biomarkers and druggable targets on key biological pathways that protect function, we aim to develop precise interventions that can slow biological aging and promote healthy aging.
Metabolomic Age and Predicting Health and Lifespan
Editor: Can you elaborate on the concept of metabolomic age and its potential to predict health and lifespan?
Dr. Yohan Santin: Metabolomic age is persistent by analyzing metabolic profiles or “metabolomes”. Recent studies suggest that metabolomic age can predict age-related morbidity and life span more accurately than chronological age. We examined associations with multiple health and aging markers like telomere length and frailty, providing a comprehensive understanding of how different biological signals influence aging and disease advancement.
Current Research Findings and Implications
Editor: How can the data from the inspire-T cohort contribute to aging research and clinical practice?
Dr. Yohan santin: The data from the inspire-T cohort represent a meaningful advancement in identifying markers of aging in both good and poor health. These findings could contribute to the development of prevention strategies and personalized treatments for each individual.Moreover, the study has enabled the creation of a biobank, making tissue samples and related databases accessible to the scientific community. Better understanding the mechanisms of aging through these resources offers promising perspectives for slowing biological aging through lifestyle adjustments and targeted treatments.
Sex-Specific Determinants of Biological Aging
Editor: Can computational and digital analyses help define sex-specific functional determinants of biological aging?
Dr.Yohan Santin: Absolutely. Our computational and digital analyses in the INSPIRE mouse cohort help identify sex-specific functional determinants of biological aging. By integrating multiple physiological data layers, we can better understand how biological mechanisms may differ between sexes, which can lead to more precise and effective interventions for both men and women.
Conclusion
Editor: what are the main takeaways from our discussion? What should people no about the current advancements in aging research?
Dr. Yohan Santin: The main takeaways are that aging is an intricate process involving multiple biological signals and that different organs age at different rates. our research and initiatives like IHU HealthAge aim to decode these processes to identify biomarkers and effective treatments. Computational and digital analyses hold tremendous potential for understanding how aging affects individuals differently,paving the way for personalized,preventive,and therapeutic strategies.
