Cristiano Ronaldo (9 and 31), Joao Felix (15), Bernardo Silva (18), Ottavio (77) and Rafael Leao (89) scored the goals of the Portuguese national team.
The Portuguese star, 38, increased his tally of international goals to 122.
In the same group, Slovakia beat Bosnia and Herzegovina 2-0, Iceland and Liechtenstein 7-0.
The Portuguese national team is at the top of the group with 6 points.