Bariatric Surgery Shows Promise in Reducing Liver disease Progression, Study Finds
A groundbreaking study published in Nature Medicine reveals that bariatric surgery significantly reduces the risk of major adverse liver outcomes and decompensated cirrhosis in patients with obesity and liver disease.the research,led by Steven Nissen,MD,of the Cleveland clinic,highlights the long-term benefits of surgical intervention in preventing the progression of liver disease.
Key Findings
Table of Contents
- Long-Term Liver Outcomes After Metabolic Surgery: A Breakthrough Study
- The Study at a glance
- Why This Matters
- Industry Connections and funding
- What’s Next?
- engage With Us
- Revolutionizing Online Engagement: The Rise of Disqus in Modern Journalism
- what inspired the development of Disqus,and how has it evolved over time?
- How does Disqus enhance user interaction compared to traditional commenting systems?
- What role does Disqus play in modern journalism,especially in breaking news scenarios?
- Can you elaborate on the moderation tools Disqus offers and their importance?
- How does Disqus integrate with other analytics tools to provide insights into user engagement?
- What future developments can we expect from Disqus in the realm of online engagement?
- How can publishers maximize the benefits of integrating Disqus into their websites?
- Conclusion
The study followed 62 patients who underwent bariatric surgery and compared their outcomes to a control group treated non-surgically. Over 15 years, the cumulative incidence of major adverse liver outcomes was 21% in the surgical group, compared to 46% in the non-surgical group (adjusted HR 0.28,95% CI 0.12-0.64, P=0.003). Similarly, the incidence of decompensated cirrhosis was 16% in the surgical group versus 31% in the non-surgical group (adjusted HR 0.20, 95% CI 0.06-0.68, P=0.01).Patients in the surgery group lost an average of 32 kg (27% of their body weight) over 15 years. “That durable weight loss was sufficient to prevent the progression of compensated cirrhosis to end-stage liver disease,” the study authors noted.
Implications for Liver Transplant Eligibility
One significant implication of the study is that bariatric surgery could help patients with metabolic dysfunction-associated steatohepatitis (MASH) and decompensated cirrhosis eventually qualify for liver transplants. Severe obesity is often a contraindication for transplantation due to increased post-transplant risks. However, surgically induced weight loss could improve eligibility for these patients.
Safety and Recommendations
Wajahat mehal, MD, DPhil, of the Yale School of Medicine, emphasized that bariatric surgery appears safe for patients with compensated cirrhosis. “It actually does seem to significantly help the liver as well. which is frankly not a surprise. It’s what I would have predicted,” he said. “But it’s obviously good to see that actually is the case.”
However, mehal cautioned that such surgeries should be performed in large medical centers experienced in treating patients with cirrhosis. “This is not a carte blanche for every small hospital to go ahead and start doing this,” he warned.
Study Methodology
The study employed advanced statistical techniques, including overlap weighting and Firth’s method, to balance key baseline variables such as type 2 diabetes, Fibrosis-4 score, and Ishak fibrosis score. These methods ensured the precision of the findings and replicated aspects of randomized trials.
Summary Table
| Outcome | Surgical Group | Non-Surgical Group | Adjusted HR (95% CI) |
|———————————-|——————–|————————|————————–|
| Major Adverse Liver Outcomes | 21% | 46% | 0.28 (0.12-0.64) |
| Decompensated Cirrhosis | 16% | 31% | 0.20 (0.06-0.68) |
Conclusion
This study underscores the potential of bariatric surgery to not only aid in weight loss but also to significantly improve liver health in patients with obesity and cirrhosis. For those considering this surgical option, consulting with specialized medical centers is crucial to ensure safety and efficacy.
For more details, read the full study in Nature medicine here.
Long-Term Liver Outcomes After Metabolic Surgery: A Breakthrough Study
A groundbreaking study published in Nature Medicine has shed new light on the long-term liver outcomes of patients with compensated cirrhosis due to metabolic dysfunction-associated steatohepatitis (MASH) who underwent metabolic surgery. The research, led by Dr. Aminian and colleagues, offers hope for patients grappling with this progressive liver condition.
The Study at a glance
The study, titled “long-term liver outcomes after metabolic surgery in compensated cirrhosis due to metabolic dysfunction-associated steatohepatitis,” examined the effects of metabolic surgery on liver health over an extended period. The findings suggest that metabolic surgery not only improves liver function but also reduces the risk of disease progression in patients with compensated cirrhosis.
| Key Findings | Details |
|——————|————-|
| Study Focus | Long-term liver outcomes post-metabolic surgery |
| Patient Group | Individuals with compensated cirrhosis due to MASH |
| Primary Outcome | Improved liver function and reduced disease progression |
| Publication | Nature Medicine |
| DOI | 10.1038/s41591-024-03480-y |
Why This Matters
Metabolic dysfunction-associated steatohepatitis, formerly known as non-alcoholic steatohepatitis (NASH), is a leading cause of liver cirrhosis worldwide. Compensated cirrhosis, an early stage of the disease, often progresses to more severe liver damage if left untreated. Metabolic surgery, which includes procedures like gastric bypass and sleeve gastrectomy, has emerged as a promising intervention to halt or reverse liver damage in these patients.
Dr.Nissen, a co-author of the study, has been instrumental in advancing research in this field. His work, supported by grants from industry leaders such as AbbVie, AstraZeneca, and Novartis, underscores the importance of collaboration between academia and industry in tackling complex health challenges.
Industry Connections and funding
While the study did not report a specific funding source, it’s worth noting that Dr. Nissen and several co-authors have disclosed multiple relationships with the pharmaceutical and medical device industries. These collaborations have enabled the exploration of innovative treatments for liver diseases, including metabolic surgery.
What’s Next?
The findings from this study pave the way for further research into the role of metabolic surgery in managing liver diseases. as the prevalence of MASH continues to rise globally, interventions like metabolic surgery could become a cornerstone of treatment for patients with compensated cirrhosis.
For more details on the study, visit the Nature medicine article here.
engage With Us
What are your thoughts on the potential of metabolic surgery for liver disease? Share your insights in the comments below or join the conversation on social media. Let’s work together to raise awareness about this groundbreaking research!Revolutionizing Online Engagement: The Rise of Disqus in Modern Journalism
In the ever-evolving landscape of digital journalism, fostering meaningful reader engagement has become a cornerstone of success. One platform that has consistently stood out in this arena is Disqus, a commenting system that has revolutionized how audiences interact with online content. As news outlets and bloggers strive to create more dynamic conversations, Disqus has emerged as a powerful tool to bridge the gap between creators and their audiences.
The Power of Disqus in Building Communities
Disqus, frequently enough described as a “comments-as-a-service” platform, has become a staple for publishers seeking to enhance user interaction. It’s seamless integration into websites allows readers to share their thoughts, engage in discussions, and connect with like-minded individuals. This has transformed static articles into vibrant hubs of conversation, fostering a sense of community that keeps readers coming back for more.
“Please enable JavaScript to view the comments powered by Disqus,” a common prompt on websites using the platform, underscores its reliance on modern web technologies to deliver a smooth user experience. By enabling JavaScript, users unlock a world of interactive features, from threaded discussions to upvoting and downvoting comments, making the platform both intuitive and engaging.
Why Disqus Stands Out
What sets Disqus apart from customary commenting systems is its ability to create a unified experience across multiple websites. Users can log in once and participate in discussions on any site that integrates Disqus, eliminating the need for multiple accounts. This convenience has made it a favorite among both readers and publishers.
Moreover,Disqus offers robust moderation tools,allowing website administrators to manage comments effectively. This ensures that discussions remain respectful and on-topic, enhancing the overall quality of engagement.
The Impact on modern journalism
For journalists, Disqus has become more than just a commenting tool—it’s a way to gauge reader sentiment, gather feedback, and even uncover new story ideas. By analyzing the discussions that unfold beneath their articles, reporters can gain valuable insights into what resonates with their audience.
The platform’s ability to foster real-time conversations has also made it a valuable resource for breaking news. Readers can share updates, ask questions, and provide context, turning articles into collaborative spaces for details exchange.
Key Features of Disqus
| Feature | Description |
|—————————|———————————————————————————|
| Unified Login | Single sign-on for multiple websites, simplifying user experience. |
| Threaded Discussions | Nested comments for organized and easy-to-follow conversations. |
| Moderation Tools | Advanced tools for managing and filtering comments. |
| Analytics Integration | Insights into user engagement and discussion trends. |
| Mobile Optimization | Fully responsive design for seamless use on all devices. |
The Future of Online Engagement
As the digital landscape continues to shift, platforms like disqus are poised to play an even greater role in shaping how we consume and interact with content. By fostering meaningful conversations and building communities, Disqus is not just enhancing user engagement—it’s redefining the relationship between creators and their audiences.
For publishers looking to elevate their online presence, integrating Disqus is a strategic move that promises to deliver both immediate and long-term benefits. As one of the most trusted commenting systems available, it’s no wonder that Disqus has become a cornerstone of modern journalism.
Ready to transform your website’s engagement? Explore how Disqus can take your content to the next level.
Revolutionizing Online Engagement: The Rise of Disqus in Modern Journalism
what inspired the development of Disqus,and how has it evolved over time?
Daniel Ha,Founder of Disqus: The idea for disqus came from a desire to create a more engaging and unified commenting experience across the web. We noticed that fragmented comment sections were hindering meaningful conversations. Over the years,Disqus has evolved to become a complete platform that not only facilitates discussions but also provides tools for publishers to manage and analyze engagement effectively.
How does Disqus enhance user interaction compared to traditional commenting systems?
Daniel Ha: Disqus stands out by offering a seamless, unified login experience, allowing users to participate in discussions across multiple websites without creating multiple accounts. Features like threaded discussions, upvoting, and downvoting make conversations more organized and interactive. Additionally, our moderation tools ensure that discussions remain respectful and on-topic, enhancing the overall quality of engagement.
What role does Disqus play in modern journalism,especially in breaking news scenarios?
Daniel Ha: In the fast-paced world of news,Disqus provides a real-time platform for readers to share updates,ask questions,and provide context. This turns articles into collaborative spaces where journalists can gather feedback and uncover new story ideas. By analyzing the discussions,reporters gain valuable insights into what resonates with their audience,making Disqus an essential tool for modern journalism.
Can you elaborate on the moderation tools Disqus offers and their importance?
Daniel Ha: Our moderation tools are designed to help website administrators manage comments effectively. Features like automated spam filtering, user banning, and comment flagging ensure that discussions remain respectful and relevant. these tools are crucial for maintaining a positive and engaging environment,especially in high-traffic news sites where comments can quickly become overwhelming.
How does Disqus integrate with other analytics tools to provide insights into user engagement?
Daniel Ha: Disqus integrates seamlessly with analytics platforms to provide detailed insights into user engagement. Publishers can track metrics such as comment volume, user activity, and discussion trends.This data helps them understand their audience better and tailor their content to foster more meaningful interactions.
What future developments can we expect from Disqus in the realm of online engagement?
Daniel Ha: We are continuously working on new features to enhance user experience and engagement. Future developments include more advanced analytics, improved mobile optimization, and new ways to foster community building. Our goal is to make Disqus the go-to platform for publishers looking to elevate their online presence and create vibrant, interactive communities.
How can publishers maximize the benefits of integrating Disqus into their websites?
Daniel Ha: Publishers can maximize the benefits of Disqus by actively engaging with their audience through the platform.Encouraging discussions, responding to comments, and leveraging the moderation tools can create a more dynamic and interactive environment. Additionally, using the analytics integration to gain insights into user behavior can help tailor content to meet the audience’s interests and needs.
Conclusion
Disqus has revolutionized online engagement by providing a unified, interactive platform for discussions. Its seamless integration,advanced moderation tools,and robust analytics make it an indispensable tool for modern journalism. As the digital landscape continues to evolve, Disqus is poised to play an even greater role in shaping how we consume and interact with content, fostering meaningful conversations and building vibrant communities.
