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BA.2.86 (Pirola): Assessing the Global Outbreak Potential and Mutation Characteristics

Assoc. Prof. Dr. Thira Woratanarat, Faculty of Medicine Chulalongkorn University posted a Facebook stating that it assessed the outbreak situation of BA.2.86 (Pirola).

1. Detection report

Information until this morning Detections have been reported in Israel, Denmark, UK, USA (Michigan and Ohio), Japan (people traveling from Japan to Virginia. United States), South Africa and, most recently, Switzerland. (found in municipal wastewater in the county of Bern, data from Prof.Stadler T) and Thailand (found in municipal wastewater, data from Dr.Wannigama L).

Therefore, such starburst detection global coverage across the Americas, Europe, Asia and Africa

This is mainly due to the large reduction in the number of random species in surveillance systems around the world. The presence of detection reports in many countries and continents in a short period of time. As such, it indicates the possibility that BA.2.86 may spread more than expected. As a result, the World Health Organization lists this strain as Variants under Monitoring and other countries. Keep a close eye on each other. Because it could lead to a serious outbreak like when Omicron appeared after Delta. and cause many infections Including causing a number of sick people and increased deaths

2. Detection period

Reports from countries around the world have been detected since July 2023.

3. origin

undetermined Experts now estimate that this strain may have emerged between May and July 2023, possibly due to mutations in the virus in a chronic infection before infecting others. However, we still have to wait for further proof.

4. Viral Mutation Characteristics

What makes the world very worried is The mutant loci of BA.2.86 are numerous, different from other Omicron strains. Both current and former epidemic BA.2 as well as XBB.1.5 and EG.5.1 (Figure 1, Cr: Topol E, Scripps Research).

However, those mutation positions There are several positions that suggest that the performance of the virus may be improved. both in terms of immune resistance and binding to target cells

The large number of mutant loci of BA.2.86 was therefore assessed. There is a chance that it will be listed as a new strain after Omicron and may need to be upgraded to Variant of Concern (VOC) if it becomes widespread. or make the disease more severe or affect the effectiveness of existing vaccines and drugs However, it is necessary to wait for the results of the next study.

5. Assessment of the impact of the virus BA.2.86

Earlier, the World Health Organization issued a risk assessment report for BA.2.86 stating that it has the potential to cause a global outbreak.

The US CDC released a vulnerability assessment last night, August 23, 2023, stating that BA.2.86 has the potential to cause infection more easily. Both among people who have been infected with COVID-19 before, including people who have been vaccinated.

Information on the severity of the disease is not yet available.

However, if roughly assessed from the location of the virus mutation It is expected that the standard antiretroviral drugs that are available should still be used. However, it is necessary to wait for the results of further clinical studies to see if the actual situation will be as expected or not.

…with the knowledge so far It suggests that BA.2.86 could lead to a global outbreak. Due to the increased performance of the virus from the mutation so much that it is different from the original strain that has spread

Emphasize that we are all aware of the situation.

Should live a conscious life, not careless, always protect yourself.

avoid crowded places poor ventilation

Do not share food with other people outside the home.

wearing a mask correctly It will greatly reduce the risk. no matter what breed

keep in mind that infected each time Risk of getting sick, dying and having Long COVID problems that follow until deteriorating quality of life. and have long-term expenses

Not infected or re-infected It’s the best.

2023-08-24 02:56:00

#Teera #reveals #assessment #epidemic #situation #BA.2.86

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