Allergic reactions and autoimmune ailments are each circumstances that consequence from a dysfunction of the immune system.
“Within the case of autoimmunity, there may be an overreaction to a self-antigen, whereas within the case of an allergy, there may be an inappropriate response to an environmental antigen, similar to pollen or cat dander.” factors out Mrs. Eleni Komninou Rheumatologist, Director of the Clinic for Autoimmune Rheumatic Illnesses Μetropolitan Common And it continues:
“One similarity within the developmental pathways between allergy symptoms and autoimmune ailments is the involvement of immune cells within the immune response.
With allergy symptoms, the immune system reacts to innocent substances or allergens, which results in the activation of immune cells. Equally, in autoimmune ailments, immune cells might acknowledge their very own tissues as overseas and mount an immune response, leading to tissue injury and irritation.
Environmental components similar to allergens, medicine, and toxins may cause or worsen allergic reactions, whereas infections, stress, and publicity to sure environmental toxins have been implicated in triggering or worsening autoimmune ailments.
Genetic components in addition they play a task within the growth of each allergy symptoms and autoimmune ailments. Sure genes are related to an elevated danger of growing allergy symptoms or autoimmune ailments, and genetic components can have an effect on immune cell operate, the manufacturing of cytokines (inflammatory substances from cells) and different immune responses.”
Variations and similarities
“Whereas allergy symptoms and autoimmune ailments share some similarities, together with the involvement of immune cells and genetic components, they differ in some methods. A key space of curiosity between autoimmune ailments and allergy symptoms is the kind of immune cells concerned.
There’s an overlap between the cell sorts concerned in autoimmunity and allergy, and each contain pathogenic CD4 T-cells (self-reactive within the former, allergen-reactive within the latter) in addition to B cells. Further cell sorts are distinctive to every illness, similar to (eg, mast cells in allergy).
Immune cells can drive irritation and tissue injury in goal organs.
Some research have proven that folks with allergy symptoms might have an elevated danger of growing autoimmune illness and vice versa. This means that there could also be some genetic or environmental components that contribute to the event of each circumstances,” emphasizes Ms. Komnenou.
A research revealed within the journal Worldwide Evaluate of Rheumatic Illnesses discovered that sufferers with systemic lupus erythematosus (SLE), an autoimmune illness, had the next prevalence of allergic rhinitis in comparison with wholesome controls. One other research revealed in Allergy, Bronchial asthma and Scientific Immunology discovered that sufferers with rheumatoid arthritis, additionally an autoimmune illness, had the next prevalence of atopic dermatitis, a sort of pores and skin allergy.
The incidence of allergy symptoms within the basic inhabitants is sort of excessive (about 20% of People), whereas the incidence of autoimmune ailments is between 5-7%. Thus, the probability that some individuals with allergy symptoms may even develop an autoimmune illness is comparatively excessive.
Can allergy symptoms trigger autoimmunity and/or autoimmune illness flare-ups?
“Whereas there are experiences of responses to some allergens additionally inflicting autoimmune illness, such an impact of allergic responses is just not usually seen.
Total, the connection between allergy symptoms and autoimmunity is advanced and sometimes varies by particular person, particular allergen or autoimmune illness, and different components.
Not all individuals with allergy symptoms will develop autoimmune ailments, and never all autoimmune ailments are induced or worsened by allergy symptoms.
“Understanding the affiliation between allergy symptoms and autoimmune ailments may have necessary implications for the analysis, remedy and remedy of issues brought on by the immune system,” explains the specialist.
in conclusion
“It can be crucial for the coexistence and cooperation of specialist medical doctors (Rheumatologists – Allergists) as a way to diagnose and deal with sufferers, when doable, as a way to good a remedy plan,” concludes Mrs. Komninou.
#Autoimmunity #Allergic reactions #Similarities #Variations
