In addition, at least 68 people are said to be injured, according to the local emergency services.
According to the rescue company ER24, the bus must have rolled off a motorway bridge and into the river below, after a head-on collision with a van.
The accident is said to have occurred in the Louis Trichardt area of Limpopo, in the north of the country.
According to the emergency services, all the victims were confirmed dead at the scene. In addition, 68 must be damaged.
The details of the accident are not yet known. There must have been heavy rain at the scene of the accident.
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