Anti-Inflammatory Drugs Can Prevent Hypoxia

Low blood oxygen levels or hypoxia can be anticipated with the anti-inflammatory drug dexamethasone. This drug is able to suppress the response of the receptor function as an entry point for infection to red blood cells.
Research results from the Faculty of Medicine and Dentistry University of Alberta, Canada, stated that large numbers of immature red blood cells that were forced out during a Covid-19 infection lowered the patient’s oxygen saturation. These blood cells have receptors that allow them to be infected by the corona virus.
To prevent a drop in oxygen saturation due to a flood of immature red blood cells, study leader and professor at the Faculty of Medicine and Dentistry University of Alberta, Canada, Shokrollah Elahi, then tested a variety of drugs. Tests were conducted to see if the drugs could reduce the susceptibility of immature red blood cells to the virus.
“We tried the anti-inflammatory drug dexamethasone, which we know helps reduce mortality and disease duration in Covid-19 patients. We found a significant reduction in infection with immature red blood cells,” Elahi said.
When the team began exploring why dexamethasone had such an effect, they discovered two potential mechanisms. First, dexamethasone suppresses ACE2 and TMPRSS2 receptor responses to SARS-CoV-2 in immature red blood cells, thereby reducing the chance of infection.
Second, dexamethasone increases the maturity level of immature red blood cells, helping cells release their nuclei more quickly. Without a nucleus, viruses have nowhere to replicate.
Fortunately, treatment with dexamethasone to reduce viral infection in immature red blood cells did not require significant changes in the way Covid-19 patients are treated as they are today. there is / I-1