Analysis engineer M/f in hyperpolarized stable state NMR 69100 VILLEURBANNE (France) | Select a public service

Missions:
The missions shall be as follows:
i) monitoring, upkeep and evolution of the DNP instrument (each at 400 and 800 MHz – DNP probes 0.7, 1.3 and three.2 mm), coaching and consumer steering.
ii) participation in European entry tasks (as a part of the PANACEA community) and the nationwide Infraanalytics infrastructure (from finishing up superior analysis tasks in varied fields with nationwide and worldwide collaborators, to collaborating in networking actions, writing reviews, organising future tasks, and so forth.)
iii) software of latest NMR strategies to check the structure of mannequin vaccine formulations. Specifically, it will likely be a query of figuring out the structure of lipid nanoparticles, and growing new polarizing brokers and pattern preparation strategies tailored to DNP NMR of multicomponent pharmaceutical formulations. It will embrace multi-dimensional and multi-nuclear experiments (1H, 13C, 15N, 19F, and so forth.) at totally different rotational speeds and magnetic fields.

Actions:
Analysis tasks: improvement and implementation of DMN DNP exams
Interpretation and presentation of outcomes.
Supervises college students and interns.
Reception engineering in hyperpolarized stable state NMR: analysis and implementation of tasks; conducting entry assessments.
Upkeep/use of onerous grade DNP tools: efficiency monitoring, installations and upkeep work, buyer help.
Participation in widespread laboratory actions and basic operation of the spectrometer corridor.

Work context:
The appointed individual will work on the Very Excessive NMR Middle (CRMN) in Lyon, a analysis unit linked to the Ecole Normale Supérieure de Lyon, the CNRS (Nationwide Middle for Scientific Analysis) and the College of Lyon1. The CRMN hosts two DNP methods working at 400 MHz WB / 263 GHz and 800 MHz WB / 527 GHz. Each devices are outfitted with 3.2 and 1.3 mm DNP probes. A 0.7 mm DNP probe can also be out there on the 800 MHz instrument. As well as, the middle hosts 3 different NMR spectrometers (500 MHz WB, 800 MHz NB and 1000 MHz), all outfitted with tools for stable state NMR. The NMR analysis teams of the CRMN are acknowledged worldwide, particularly within the area of stable state NMR of supplies, proteins and small molecules, in addition to within the area of hyperpolarization strategies. It’s a global atmosphere and among the finest NMR platforms on this planet. The individual will work in shut collaboration with the analysis teams of Anne Lesage and Guido Pintacuda, and also will be built-in into the help crew of the spectrometer corridor, made up of three engineers and a technician.