“Kera” organized an academic meeting “Research and development of Thai herbs To advance to the international level “by the Institute of Pathological Medicine (VEDCHASART SAMUDTHARN INSTITUTE)
Wednesday, July 5, 2023 at the Miracle Grand Hotel, Bangkok Thai tabloid correspondent reported that Assoc.
Thai traditional medicine doctors and pharmacists together with the research team have presented the important research results of the “Kera” herbal medicine recipe, 6 important topics as follows:
Test results of Khera herbs in the biochemical laboratory Kasetsart University Several aspects of the pharmacological effects of Khera were studied. The activity was found to inhibit a wide range of viruses, the effect of the virus entering the cells. anti-inflammatory effect anti-cancer effect The effect causes cancer cells to die.
1.1 In the field of virus inhibition It was found to be effective in inhibiting the corona virus (SARS-CoV-2) by inhibiting the main protease enzyme that is 600 times more effective than Andrographis paniculata, 500 times higher than the drug Ritronavir, as well as inhibiting the mechanism of infection expansion. It was found that the RdRp coronavirus (SARS-CoV-2) was more effective than Favipiravir. In addition, it was found to prevent SARS-CoV-2 from entering the cells. protection against viruses entering cells At a concentration of 0.5 mg./ml., it can prevent up to 90% of the virus entering the cells, which has the potential to be further studied in terms of its utilization in the prevention of SARS-CoV-2 infection. Further, it was also found to be effective in inhibiting influenza A (H1N1) viruses, dengue fever viruses, AIDS viruses, HIV, herpes simplex viruses, HPV16 and HPV18 viruses, which are important causes of cervical cancer. Including the virus that spreads in animals, namely Feline Infectious Peritonitis (FIP) in cats that causes inflammation of the peritoneum. and feline immunodeficiency virus FIV (Feline Immunodeficiency Virus) similar to AIDS in humans.
1.2 Found anti-inflammatory effect The mechanism of inhibition of pro-inflammatory cytokines, IL-1b, IL-6 and TNF-alpha, has been shown to induce pneumonia in patients with SARS-CoV-2 infection. ) called cytokine storms, as well as affecting inflammatory conditions in the body of patients with many diseases such as SLE, rheumatoid, etc.
1.3 The effect of lowering blood pressure was found. By inhibiting the enzyme ACE (Angiotensin-Converting Enzyme).
1.4 Found anti-cancer effects By inhibiting the EGFR protein involved in promoting the growth and proliferation of many cancer cells such as urinary tract cancer, lung cancer, colon cancer. and breast cancer It was found that the drug Khura at a concentration of 100 micrograms per milliliter EGFR inhibition was comparable to erlotinib, a targeted anticancer drug. 1 mcg/mL and found the activity to stimulate P53 protein or tumor protein 53, which is a transcription factor that controls cell cycle. It also has a tumor suppressor function, making p53 important in cancer suppression of multicellular organisms.
In addition, apoptosis in cancer cells was demonstrated by the activation of the molecular switches caspase-8 and caspase-9, which are the molecular switches for apoptosis. In cancer cells, this molecule is lost. This causes cancer cells to grow continuously and not die. The concentration that can kill half of HCT116 colon cancer cells is 73 µg/ml. This is a concentration value that is considered effective and interesting for further research and development as a herbal formula for cancer.
2 research results on Study on the safety of taking Kera herbal capsules in healthy volunteers by Asst. Prof. Dr. Suriyan Sukti, Walailak University and others. in a sample of healthy volunteers The results showed that Taking 8 Kera capsules per day, equivalent to 4,000 mg per day for 14 consecutive days, is safe. By comparing blood test results, liver function, kidney function, red blood cell count, white blood cell count, CRP (C-reactive protein) and erythrocyte sedimentation count. before taking compared with after taking the drug No changes or abnormalities in toxicity were found. No adverse reactions or statistically significant differences were found.
3 research results on A comparative study of prophylactic drug exposure among people exposed to COVID-19 infection. at high risk with Khera herbs Comparison with Fah Talai Jone and vaccination by Dr. Phayong Thep-aksorn and colleagues. A total of 2,157 people were sampled, divided into 3 groups: a group receiving Khera herbs, 1,098 people (50.9%). Andrographis paniculata 848 (39.3%) and 211 (9.8%) were vaccinated, respectively, 247 (11.5%) were infected. Samples who have been exposed to an infected person and are at high risk of contracting COVID-19. who eat Andrographis Paniculata Or those who received the vaccine had a higher infection rate than those who ate the herbal formulation of Khera. Statistically significant (p<0.01)
4 research results on Efficacy and Safety of Khera Herbal Medicines on Symptoms of Coronavirus (SARS-CoV-2) Infection in the Early Stage by Dr. Rangsan Budcha, a skilled physician. Director of Democrat Hospital and team The sample was Patients infected with COVID-19 A total of 230 patients received services at Prachathipat Hospital. The patients were divided into two groups: the group taking the herbal formulation of Khera and the group taking the drug Molnupiravir. The results showed that both groups had improved symptoms of COVID-19 and were not referred for treatment for more severe symptoms. and no deaths were found. In conclusion, COVID-19 patients taking Molnupiravir or Khera herbs There is no difference in treatment efficacy. Therefore, herbs are considered an alternative treatment for patients with COVID-19.
5 research results on retrospective study The effect of Khera herbal formula on the clinical features of COVID-19 Of those infected with COVID-19 Self-quarantine at home by Dr. Suwannee Soisong and her team Study in a sample group infected with COVID-19 Delta strain. by conducting a retrospective study from a group of people infected with COVID-19 in Pathum Thani Province 2,510 people received Kera herbs. The results of the study showed that After receiving Kera herbs, symptoms were found within 7 days, representing 67 percent. During the treatment, no symptoms were found to increase. No breathing apparatus was used. no significant side effects No referrals and no patients died from COVID-19 After taking the Khera formula herbal medicine
6 research results on Comparison of the cost and effectiveness of using Khera herb with Favipiravir in the treatment of patients infected with COVID-19
By Dr. Phusadee Sathong and colleagues. The sample group was patients infected with COVID-19, Delta strain. receiving treatment in the Democrat hospital network Pathum Thani Province and Pathum Thani Provincial Administrative Organization, 4,399 people, 2,838 people use Favipiravir, 2,510 people use Khera herbal formulations. 2,799 field nurses under the supervision of the Democrat Hospital and the Democrat Hospital were tired and had to give oxygen to oxygen, 77 people, while those who used Kera herbs received drugs and stayed at home, no referrals were found. with more severe symptoms when considering the cost of treatment It was found that the patients receiving the drug used Favipiravir. with an average cost of 19,784.14 baht per person, while the Khera herbs cost an average of 750 baht per person.
All research results will be presented to the Food and Drug Administration. To register as a developed herbal product that has properties in treating COVID-19 This will promote the widespread use of herbs within the country. and exported to the international level
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2023-07-05 03:15:43
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