Home » Health » Advanced brain aging may predict dementia risk in patients with ischemic heart disease, particularly those with diabetes and obesity, according to a UK Biobank study. The research suggests “central adiposity as an indicator of visceral fat” accelerates brain aging in the presence of IHD, said lead author Elisa Rauseo, of Queen Mary University and St Bartholomew’s Hospital, London. Visceral fat promotes systemic inflammation, which could partly underlie IHD-associated brain aging and dementia, the study said. Brain scans indicating age beyond patients’ actual years could encourage anti-dementia measures among younger people, the researchers said.

Advanced brain aging may predict dementia risk in patients with ischemic heart disease, particularly those with diabetes and obesity, according to a UK Biobank study. The research suggests “central adiposity as an indicator of visceral fat” accelerates brain aging in the presence of IHD, said lead author Elisa Rauseo, of Queen Mary University and St Bartholomew’s Hospital, London. Visceral fat promotes systemic inflammation, which could partly underlie IHD-associated brain aging and dementia, the study said. Brain scans indicating age beyond patients’ actual years could encourage anti-dementia measures among younger people, the researchers said.

As we age, our brains undergo a natural process of aging that can lead to cognitive decline and an increased risk of developing conditions like dementia. But recent research has suggested that this process may be linked to heart health, with some experts suggesting that the cardiovascular systems in our bodies may play a critical role in protecting our brains as we age. In this article, we’ll explore the ways in which brain aging and heart disease are connected, and what steps we can take to improve our overall brain health as we get older.


An individual’s “brain age” may be a valuable predictor for assessing dementia risk in patients with ischemic heart disease (IHD), according to researchers. Patients with IHD, particularly those with diabetes or obesity, are more likely to demonstrate accelerated brain aging on imaging, which is linked to future risk of cognitive impairment or dementia. Although this finding supports considerable research linking IHD and cognitive decline, researchers discovered that the mechanism of accelerated brain aging was not solely due to microvascular injury. Instead, the study indicated that it was linked to visceral fat, with central adiposity being a key factor contributing to accelerated brain aging in those with IHD. This led researchers to speculate that IHD-associated accelerated brain aging and dementia may be partly due to systemic inflammation caused by adiposity promotion. These assertions present exciting possibilities for future studies exploring a potential correlation between inflammatory markers in IHD and later development of dementia. By demonstrating that MRI-derived brain age could be a powerful tool to discuss dementia risk with patients, researchers aim to identify the early signs of future cognitive deterioration, which could promote preventive behaviors sooner. Early risk awareness could be vital, particularly for younger patients, to promote necessary lifestyle changes to mitigate dementia risk. This research may contribute to discussions regarding dementia risk, potentially leading to more effective prevention strategies for patients with IHD.


In conclusion, brain aging is a natural process that cannot be avoided. However, by taking measures to maintain a healthy heart, we may also be reducing our risk of developing dementia in the future. It’s important to pay attention to our lifestyle choices, such as maintaining a healthy diet, exercising regularly, and controlling blood pressure and cholesterol levels. While there is still much to learn about the relationship between heart disease and dementia, taking care of our heart health may be the key to maintaining a sharp mind in old age.

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