According to the authors, more physical activity in preschool children could reduce their risk of infection. Parents should therefore motivate their children to do more sport and other physical activity, they advise. The cause of the protective effect may be that physical activity lowers levels of pro-inflammatory cytokines, which are associated with chronic inflammation. In addition, extracellular vesicles released by skeletal muscles, which according to recent findings can modulate the immune system, could play a role here.