Astrid Yasmine Sana’s Groundbreaking research Sheds Light on Genetic Susceptibility to Tuberculosis
On Saturday, January 11, 2025, astrid Yasmine Sana made history at Joseph Ki-Zerbo University in Ouagadougou, Burkina Faso, by defending her doctoral thesis in applied biological sciences. Her groundbreaking research, titled “Polymorphisms of genes encoding interferon Y and their implications in susceptibility to mycobacterial infections,” delves into the genetic factors that predispose individuals to mycobacterial infections, particularly tuberculosis (TB).
The defense took place before a distinguished jury of six members at the university’s Doctoral School of Sciences and Technology. Sana’s work, conducted at the Laboratory of Molecular Biology and Genetics (LABIOGENE), focused on the role of interferon gamma (IFN-γ) gene polymorphisms in TB susceptibility.
The Study: A Deep dive into Genetic Predisposition
sana’s research analyzed 168 tuberculosis patients between May 2024 and January 2025, revealing that 74.5% of the patients carried the AA genotype, a genetic variant associated with increased susceptibility to TB.
“We wanted to know which patients are likely to have tuberculosis genetically,” Sana explained. “So we worked on the polymorphisms of interferon gamma, which predisposes tuberculosis in certain humans. This polymorphism undergoes mutations, and with these mutations, the body is unable to correctly produce interferon gamma, which is a key player in the body’s fight against tuberculosis.”
Her findings highlight the critical role of IFN-γ in the immune response to TB.Mutations in the genes encoding this protein can impair the body’s ability to combat the infection, making certain individuals more vulnerable.
A Public Health Challenge in Burkina Faso
Despite decades of efforts to combat TB, it remains a important public health issue in Burkina Faso. According to the World Health Organization (WHO), TB is one of the top 10 causes of death worldwide, with Africa bearing a disproportionate burden of the disease.
Professor Florencia Djigma, president of the jury, praised Sana’s work for its originality and relevance. “the results presented today by the candidate are truly relevant.We all know that despite decades of fighting tuberculosis, it still remains a public health problem. Ther are many people each year who contract tuberculosis, and it is indeed our duty as researchers to try to better understand the genetic implications of this pathology within the burkinabe population,” she said.
Implications for Future Research and Treatment
Sana’s research opens new avenues for understanding the genetic underpinnings of TB susceptibility. By identifying individuals at higher risk, healthcare providers can develop targeted prevention and treatment strategies.This is particularly crucial in regions like Burkina Faso, were resources for combating infectious diseases are often limited.Her work also underscores the importance of molecular biology and genetics in addressing public health challenges. As TB continues to evolve, understanding its genetic basis will be key to developing more effective interventions.
key Findings at a Glance
| Aspect | Details |
|———————————|—————————————————————————–|
| Research Focus | Polymorphisms of genes encoding interferon Y and TB susceptibility |
| sample Size | 168 tuberculosis patients |
| Key Genotype Identified | AA genotype (74.5% of patients) |
| Research Period | May 2024 – January 2025 |
| Location | Joseph Ki-Zerbo University, Ouagadougou |
| Laboratory | Laboratory of Molecular Biology and Genetics (LABIOGENE) |
| Jury Verdict | Very honorable mention |
A Call to Action: Strengthening the Fight Against TB
Sana’s research is a clarion call for increased investment in genetic research and public health initiatives to combat TB. As Professor Djigma noted, “It is our duty as researchers to try to better understand the genetic implications of this pathology.”
For those interested in learning more about TB control strategies, check out this insightful article on the National Tuberculosis Control Program in Burkina Faso.
Conclusion
Astrid Yasmine Sana’s doctoral thesis is a testament to the power of scientific research in addressing pressing public health challenges. By uncovering the genetic factors that contribute to TB susceptibility, her work paves the way for more targeted and effective interventions. As Burkina Faso and the global community continue to battle TB, studies like Sana’s will be instrumental in turning the tide against this persistent disease.
For more updates on groundbreaking research and public health initiatives, stay tuned to our platform. Together, we can build a healthier future.Groundbreaking Genetic Research Led by Dr. Tani sagna yields Promising Results
In a significant stride for genetic research,Dr. Tani Sagna,a renowned molecular biologist and associate researcher,has announced the accomplished completion of a groundbreaking study. The project, which began in 2021 with a submission to the World Health Academy, has yielded results that could pave the way for future advancements in genetic science.
Dr. Sagna, who serves as the thesis director for this project, expressed her satisfaction with the outcomes. “I am pleased with the results obtained at the end of the study,” she stated, emphasizing her commitment to continuing research into other genetic aspects. Her work has already garnered significant attention, with over 66 publications and 638 citations to her name, as highlighted on her ResearchGate profile.The study,conducted in collaboration with biomedical technologist Astrid Yasmine Sana,focused on critical genetic factors. Sana, who works at the Medical Center with Surgical Antenna (CMA) in Saponé, played a pivotal role in the research. Her expertise in biomedical technology was instrumental in achieving the study’s objectives.
This research is part of a broader effort to address pressing health challenges in Burkina Faso.Dr. Sagna’s work aligns with recent studies, such as the detection of pulmonary tuberculosis and COVID-19 co-infection in Ouagadougou, as detailed in a World Health Academy |
| Lead Researcher | Dr. Tani Sagna |
| Collaborator | Astrid Yasmine Sana |
| Focus | Genetic research |
| Outcome | Promising results, with plans for further research into genetic aspects |
Dr. Sagna’s dedication to advancing genetic research underscores the importance of scientific collaboration in addressing global health challenges. her work not only contributes to the scientific community but also offers hope for innovative solutions to complex health issues.
For those interested in staying updated on Dr. Sagna’s research and other scientific breakthroughs, follow Burkina 24’s WhatsApp channel for the latest updates.
As the scientific community eagerly awaits the next phase of Dr. Sagna’s research, her work serves as a testament to the power of perseverance and innovation in the pursuit of knowledge.
