A study issued by the Stanford University School of Medicine revealed the effectiveness of antibodies in determining the severity of your infection with the Coronavirus, according to what was stated on the site medical express.
The study said that the antibodies that target the basic viral protein are severely affected by the infection, since the antibodies preferentially target a different part of the virus in mild cases of infection, compared to severe cases, which fade away significantly within several months.
The study found that there is a relationship between the course of the disease and the immune response of the patient, which results in concerns about whether the infection can be re-infected, the relationship of antibody tests to detect previous infection with controlling the size of the spread of the epidemic, and the effectiveness of vaccines to maintain a preventive immune response for a long time.
The study relied on analyzing the levels of viral RNA in the throat swabs and blood samples of the patient, as it was found that severely infected people have low levels of antibodies that target the spike protein that the virus uses to enter human cells, compared to the number of antibodies that target the proteins of the inner envelope of the virus. .
While the study showed that the coronavirus is linked to human cells through proteins called the spike protein, as this protein binds to a receptor in human cells called ACE2, Which allows the virus to enter and infect the cell, as soon as it penetrates the body, the virus throws its outer envelope to reveal an inner covering that encases its genetic material.
She also explained that the virus is able to make the protein in the cell to produce more viral particles, which are then released to infect other cells, and here the antibodies that recognize the spinal protein work from stopping the infection of cells, which means that the severity of the disease is related to the percentage of antibodies that It recognizes spike protein domains compared to other non-protective viral targets.
And the study showed that people with mild disease had a higher percentage of antibodies to anti-spike.
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