A study conducted by researchers in Argentina and published by bioRxiv revealed that the new medicinal formulations of nasal spray are useful for treating Corona virus 2 (-CoV-2) .The site indicated that the use of nasal spray medicine has been tried on pig animals, as the drug consists of high concentrations of a substance Ivermectin (IVM) It is an anti-parasite drug in the nasopharyngeal tissue – it was found that the nasal spray is safe and well-tolerated in pigs, and no local or systemic adverse events were observed in animals, which makes it useful to prevent the entry of the Corona virus. -CoV-2 Through the nose.
Nasal spray
The supervisor of the study said : “As far as we know, this is the first time that a nasal spray formulation has been developed IVM Its safety and pharmacological performance are determined in a pig model, which is the most appropriate animal model to be used in research translated in humans.
According to the results published on the site bioRxiv Sprays have been a safe and effective treatment for tropical diseases like scabies and parasitic worms for decades..
Over recent years, emerging knowledge has directed use reorientation IVM Towards the treatment of other diseases, the drug’s antibacterial and antiviral activities have been observed experimentally.
“Moreover, there is now information available from a randomized clinical trial on antiviral activity in virus-infected patients -CoV-2 ” ،.
-CoV-2 initially colonizes in the nasopharynx
Since the first cases were identified for -CoV-2 In Wuhan, China, late last year, studies showed that the virus initially colonizes the tissues of the nasopharynx, and from there, the virus can be transmitted before any symptoms appear..
With multiply -CoV-2 In this tissue, the initial symptoms such as a dry cough and fever develop, along with colonization of the lung parenchyma.
Given the gateway to the virus, controlling the nose from the beginning can reduce the viral load at the beginning of the infection, and prevent the virus from multiplying and transmitting, and then the disease worsens“.
Safety and pharmacokinetics test for piglets
The team evaluated the safety and pharmacokinetic performance of a single or double dose of nasal spray, administered orally in pigs..
The researchers say that piglets were chosen as a test animal because pig has anatomical and physiological similarities to humans, and is one of the animal species most used in translated research..
Treatment was well tolerated, with no local or systemic adverse events during the entire study period, whether the drug was administered orally or with a single or double dose of the spray formulation..
After nasal administration, the highest concentrations were determined, and a second dose of the spray significantly increased the concentration of the spray and the active substance in the nose and lung tissue, compared to using a single dose..
The team said: “Compared with oral administration, intranasal administration in humans may provide a rapid, high and sustained concentration of the active substance.”
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