The study does not show a causal relationship.
Erasmus University scientists have found that people with low bone density may have an increased risk of developing dementia compared to people with higher bone density. The study is published in the journal Neurology.
The study involved 3651 elderly people from the Netherlands. On average, over 11 years of follow-up, dementia developed in 688 people (19%).
The researchers assessed the patients’ bone density using x-rays. Participants also completed questionnaires every four to five years and underwent physical and dementia tests.
1211 people had low body density. 90 of them developed dementia within 10 years, compared to 57 of 1211 people with high bone density.
After adjusting for factors such as age, gender, education, other medical conditions, medications, and heredity, the researchers found that those with the lowest bone density were 42% more likely to develop dementia than those with the highest bone density.
The scientists noted that their study does not show a causal relationship. However, it is possible that bone loss may occur as early as the earliest stages of dementia, years before any clinical symptoms appear.
If so, bone loss could be an indicator of dementia risk, and people with bone loss could be referred for screening.
“Low bone density and dementia are two conditions that typically affect older adults at the same time, especially as bone loss is often increased due to physical inactivity and poor nutrition during dementia. However, little is known about the bone loss that occurs in the pre-dementia period. Our study showed that bone loss does occur before dementia and is thus associated with a higher risk of developing dementia.
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