A new study published in the Journal of Alzheimer’s Disease found that apathy is a predictor of Alzheimer’s disease in older adults with mild cognitive impairment (MCI). During the study period, 36% of MCI patients with apathy developed Alzheimer’s disease, compared to only 14% of those without apathy.

Apathy is often considered a normal part of aging, but for some individuals, it may signal the first warning signs of Alzheimer’s disease, according to new research. Scientists have found that apathy, or a lack of motivation or interest in activities, is a red flag for the disease in some people, and early detection could help patients receive treatment earlier, potentially slowing the progression of the disease. While more research is needed to better understand the link between Alzheimer’s and apathy, these findings highlight the need for increased awareness and screening for the condition in older adults.


A new study has identified a link between apathy and the development of Alzheimer’s disease in people with mild cognitive impairment (MCI). The study, published in the Journal of Alzheimer’s Disease, analysed 1,092 individuals diagnosed with MCI (slightly more women than men, with an average age of almost 72) over an eight-year period. During this time, close to one-fifth of people converted from MCI to Alzheimer’s disease. Of those individuals who displayed apathy, 36% went on to develop the disease compared to only 14% of those without apathy. The shift to Alzheimer’s was also faster in those with apathy, with an average of almost 4 years versus an average of almost 7 years for those without. “In older adults with MCI, we found that apathy was a predictor of who would be more likely to develop Alzheimer’s disease,” said senior study author Antonio Teixeira.

Apathy is defined as “loss of interest and reduction in goal-directed behaviours.” Neuropsychiatric symptoms, such as apathy, are present in as many as 85% of MCI patients and are also found in the early stages of Alzheimer’s. As such, family members and carers of individuals who display apathy are urged to bring the issue to the attention of a physician, psychologist or other health professional, as the presence of apathy “could either prompt further investigation or at least closer following”. Making assumptions about the reason for the patient’s apathy could lead to incorrect diagnosis and treatment, which is why it is essential that caregivers seek further advice.

Claire Sexton, senior director of scientific programs and outreach at the Alzheimer’s Association, said the study was significant in its study of a more diverse population than previous research into the issue. Sexton believes that apathy is only one of several factors contributing to the progression from MCI to Alzheimer’s dementia. Nonetheless, the Alzheimer’s Association advises clinicians and family caregivers to monitor for and manage behavioural and neuropsychiatric symptoms, including apathy, throughout the disease course, which can be an important part of maintaining or improving everyone’s quality of life.


As we delve deeper into the complexities of Alzheimer’s disease, new insights and potential red flags are continuously emerging. Apathy, or a lack of interest and motivation, has been identified as a potential early warning sign of Alzheimer’s in some individuals. While more research is needed to confirm this link and fully understand its implications, it is a reminder of the importance of identifying and addressing cognitive changes early on. If you or a loved one are experiencing persistent apathy or other cognitive symptoms, seeking medical attention and support can be key to early detection and management of Alzheimer’s disease. By staying vigilant and proactive, we can work towards a future where Alzheimer’s is not just treatable, but truly preventable.