A new study from the University of Bristol has identified memory impairment associated with steroid use. Glucocorticoids, which are commonly prescribed to treat a range of conditions, are known to have an adverse effect on mood, sleep, and memory. The study found that even a relatively short course of prescribed steroids led to impaired memory performance, with the hippocampus significantly altered by the treatment. The findings show potential for the identification of drugs that could be used to treat certain memory disorders.

Steroids are commonly used by athletes, bodybuilders, and individuals seeking certain medical treatments. However, a growing body of research suggests that long-term use of these substances may come with some cognitive risks. A new study has found that the long-term use of steroids can impair memory function. The findings add to a growing body of literature that raises concerns about the potential cognitive consequences of long-term steroid use. Here, we delve further into this topic, reviewing the scientific literature and discussing potential implications for athletes, medical professionals, and individuals considering steroid use.


Steroids have been found to impair hippocampal activity, leading to memory deficits, according to a study led by the University of Bristol. Glucocorticoids, commonly known as steroids, are frequently prescribed to manage allergies, asthma, arthritis and inflammatory bowel disease, but they can have negative effects on mood, sleep and memory, with many patients reporting cognitive decline and memory impairment. Using rodent models, the University of Bristol found that even a relatively short period of steroids led to impaired memory performance, and that the patient’s experience of cognitive decline was related to the steroid rather than their medical condition. The team found that the active times of day were critical for the stimulation of hippocampal synaptic plasticity, but that long-term steroid treatment could block the effectiveness of the treatment to all times of day, contributing to the brain fog experienced by many patients on steroids. The research also identified the impact of circadian regulation on the hippocampus and its function, and suggests that better matching prescribed courses of drugs to endogenous steroid release could have a significant impact on treatment outcomes. Funding was provided by the Wellcome Trust and the Medical Research Council.


In conclusion, while steroids may provide numerous benefits when used appropriately, their long-term use could have significant implications on our cognitive health, specifically our memory functions. As more research emerges regarding the relationship between steroids and cognitive decline, it is important for individuals and medical professionals alike to remain vigilant about the potential risks associated with prolonged use. In the meantime, maintaining a healthy lifestyle and seeking medical advice when necessary can help mitigate some of the negative effects of steroid use on our memory and overall well-being.