The City of Hope Medical Center (City of Hope Medical Center), the largest cancer research institution in the United States, announced that they have successfully developed a small pill called “AOH1996”, which can kill up to 70 types of solid cancer cells , tumors, while not harming other cells, is considered a new hope for curing cancer within the next 10 years.
Cancer savior｜New drug AOH1996 can kill 70 kinds of cancer cells, 2 major effects are the strongest
After 20 years of research, Professor Linda Malkas and her team finally succeeded in targeting a special protein “Proliferating Cell Nuclear Antigen” (PCNA) in DNA to destroy it with drugs . Professor Mallorcas pointed out that it is known that PCNA is a protein in DNA responsible for replication, repair, chromatin remodeling and cell cycle regulation, that is, it is responsible for controlling the growth of cancer cells/tumors. She described that PCNA is like a terminal building with multiple boarding gates, but the newly developed drug “AOH1996” is like a blizzard, which can directly shut down the terminal and not allow flights carrying only cancer cells to take off .
“AOH1996” “kills cancer cells fundamentally” by affecting PCNA, destroying the normal reproductive cycle of cancer cells, preventing cell division with damaged DNA, and preventing defective DNA replication. It can not only inhibit tumor growth, but also interact with other cancers The combination of treatments, and more importantly, “does not produce toxicity”. More than 70 different cancer cells, including those from breast, prostate, brain, ovary, cervix, skin and lung, have been tested in the laboratory and found to be effective in all effective.
Cancer savior｜New drug AOH1996 needs 2 years of clinical trials to cure cancer within 10 years
The origin of the drug name “AOH1996″ is to commemorate a little girl Anna Olivia Healy (Anna Olivia Healy) who died of neuroblastoma. Professor Mallorcas said that when she was intern, she met When Anna’s father found out that she was studying breast cancer, he immediately gave her an experiment grant, hoping that she could study more neuroblastoma. Professor Mallorcas said, “I knew I wanted to do something for that little girl. something special”.
At present, “AOH1996” is only going to undergo Phase I clinical trials, which are expected to last for at least 2 years. The first patient participating in the test took the drug in October last year. The drug still needs to undergo strict safety and effectiveness tests and large-scale Clinical trials will not be widely used in clinical treatment, but scientists are still optimistic that the drug can cure cancer within 10 years.
Founded in 1913, City of Hope Medical Center is one of the largest non-profit cancer research institutions in the United States and the No. 1 cancer treatment hospital on the West Coast of the United States. It has more than 300 research patents, including synthetic insulin and synthetic growth hormone. With the medical milestones of Genesis, a variety of widely used anti-cancer drugs have been developed, such as Herceptin (breast cancer drug), targeted drug Avastin (Avastin), etc. Last year, it invested 390 million yuan to acquire the Cancer Treatment Centers of America (CTCA), which has locations across 4 states in the United States and can provide treatment services for about 115,000 patients every year.
This article is reproduced with the authorization of “ettoday”
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2023-08-15 14:04:55
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