THE ESSENTIAL
- Fezolintant is a promising new non-hormonal treatment for menopausal hot flashes. By blocking a specific brain protein, it significantly reduces the frequency and intensity of these discomforts.
- This drug has shown its effectiveness from the first days of treatment and is well tolerated. It represents an interesting alternative for women who cannot or do not wish to take hormones.
- Although fezolinetant is a major advance in the treatment of menopausal symptoms, it only treats hot flashes and is not a substitute for regular medical monitoring.
Hot flashes, the sudden sensations of intense heat that often accompany menopause, can significantly affect women’s quality of life. While hormone replacement therapy (HRT) is often prescribed, it is not suitable for all women. In this respect, fezolinetant may help many women.
How does fezolinetant work?
Fezolintant works by blocking a brain protein called neurokinin-3 (NK-3). This protein plays a key role in regulating body temperature. By inhibiting its action, Fezolintant helps reduce the frequency and intensity of hot flashes.
Promising results
A recent study evaluated the efficacy of fezolinetant in 453 postmenopausal women with moderate to severe hot flashes. The results were encouraging: women treated with fezolinetant experienced a significant reduction in the frequency and severity of their hot flashes from the first day of treatment. This efficacy was maintained throughout the 24-week study.
The main advantages of fezolinetant are:
- Speed of action: The beneficial effects are observed from the first days of treatment.
- Safety: Fezolintant was well tolerated by study participants, with no major side effects.
- Specificity: It specifically targets hot flashes, without the side effects associated with hormone therapy.
An alternative for whom?
Fezolintant is particularly suitable for women:
- Suffering from moderate to severe hot flashes.
- Unable to benefit from hormone replacement therapy due to medical contraindications (breast cancer, high blood pressure, etc.).
The limits of fezolinetant
It is important to note that fezolinetant only treats hot flashes. It has no effect on other symptoms of menopause such as mood swings or vaginal dryness.
Additionally, although study results are promising, further research is needed to assess its effectiveness over the long term and in different populations.
The Future of Hot Flash Treatment
The arrival of fezolinetant marks a significant advance in the treatment of hot flashes. This new molecule offers a safe and effective alternative for women who cannot or do not wish to take hormones.
However, it is important to remember that every woman is unique and treatments must be personalized. It is therefore essential to consult a doctor to discuss the different treatment options available and choose the one that is best suited.
Fezolintant opens new perspectives for the treatment of menopausal hot flashes. By offering a non-hormonal, effective and well-tolerated alternative, it significantly improves the quality of life of many women.
