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The study took blood samples from more than 1,470 pregnant women at a Pennsylvania Hospital between April and August 2020, where researchers found and analyzed COVID-19 antibodies in 83 new mothers.
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It is known that about 87% of newborns show reports of COVID-19 antibodies in their umbilical cord. The number and nature of antibodies in newborns depend on the type and amount of antibodies present in the mother during her pregnancy.
“Our findings demonstrate the potential for maternal-derived antibodies to provide neonatal protection from SARS-CoV-2 infection and will help inform guidelines for neonatal management and vaccine trial design during pregnancy,” the researchers said quoted by the Times of India, Saturday (6/2). ).
Immunoglobulin G (IgG) is a type of antibody found in cord blood that helps protect the body from various infections. As per a recent study, immunoglobulin G (IgG) was detected in 83 of 1,471 women (6%) at delivery, and IgG was found in the umbilical cord blood of 72 of 83 newborns (87%).
This reflects the same levels of IgG in mothers and newborns. Eleven babies tested negative for these antibodies either because of low IgG levels in their mothers or because of low levels of antibody production by the mothers.
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In contrast, no IgM antibody, which is the first antibody to appear in response to initial exposure to an antigen, was found in maternal cord blood. This suggests that the mother does not infect her child during pregnancy because IgM antibodies cannot be transferred across the placenta.
“Further research is needed to determine whether SARS-CoV-2 antibodies protect against newborn infection. If so, at what concentrations, and whether the transplacental kinetics of antibodies obtained from vaccines are similar to those of naturally acquired antibodies,” the researchers said.
(tdy)
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