A breakthrough for one of the deadliest forms of breast cancer.
A breakthrough has allowed researchers to identify the exact gene responsible for one of the deadliest forms of breast cancer.
Australian researchers have discovered the gene responsible for a particularly bad form of hormone-sensitive breast cancer, and it is believed that this finding may also provide a genetic pathway to detect other cancers in the future.
In 2012, researchers created a breast cancer classification called IntClust, in which they divided the disease into 10 different subgroups.
Among them are estrogen receptor-positive (ER +) cancers called IntClust2, which feature a piece of DNA on chromosome 11, with one gene in particular, called AAMDC, a potential calling card for some of the more intractable cancers. known to humans.
The scientists examined more than 100 breast cancer samples and tested the amount of AAMDC expressed. Approximately 25% of the tumors analyzed were found to have amplified levels of AAMDC, and the majority were ER + tumors.
The team then set out to work to reduce the levels of AAMDC in the transplanted breast cancer cells from the mice. Indeed, the cells were inhibited and what is known as “programmed cell death” died shortly thereafter, that is, death when it was assumed that they were not resistant to treatment.
The team concluded that high levels of AAMDC protected cancer from hormonal therapies that would starve other less aggressive species and cause them to die, and epigenetics scientist Pilar Blancafort described the gene as the “survival kit. ”For the most unsightly breasts. Cancer.
“AAMDC can protect cancer cells from death and sustain their growth when a tumor is placed in conditions where nutrients are in short supply and when it is starved for the hormone estrogen that kills most hormone-sensitive cancers,” he said. Blancafort.
Amplified levels of AAMDC are also found in ovarian, prostate, and lung cancers and thus may serve as a series of clues that would allow clinicians around the world to track such aggressive and resistant cancers faster and buy time. Valuable for further targeting and targeting. Now, thanks to this research, an effective treatment.
“We hope this significantly improves the poor outcomes these patients are currently experiencing,” said Blancafort.
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