New studies show that vitamin D can work wonders for sick people Corona Virus COVID-19, both in managing symptoms and in preventing infection.- According to the timesofindia website, that is among the patients Corona infection COVID in hospital, 20 people have developed acute respiratory distress syndrome (ARDS) and need to be admitted to the intensive care unit, and acute respiratory distress syndrome is a condition in which fluid collects in the lungs, and it is associated with either a cell storm or a bradykinin storm.-
Cytokines are proteins that send signals to cells and put the body’s immune system to work. Bradykinins are proteins that lead to inflammation.
Overexpression of these proteins, called a cytokine storm or bradykinin storm, can lead to the failure of many organs.
Works Vitamin D As an immunomodulatory agent it could have protective effects against these severe outcomes in patients with COVID-19.-
Here … how does vitamin D help prevent multiple organ failure?
Play Vitamin D An important role in the activation and functioning of the immune system, vitamin D inhibits the function of T helper cell type 1 (Th1), which is involved in cellulitis.- Studies have found that the stimulant form of Vitamin D It is directly related to inhibition of two cytokines, gamma-interferon and IL-2 that can lead to organ failure. ‘-
During a viral infection, the inactive vitamin D is converted into the active form by cells in the alveoli – which are small air sacs in our lungs and lead to overexpression of another compound called cathlycidine. Oxygenation or excess oxygen supply.
Studies in kidney patients and mice with diabetes have shown an increase in the expression of angiotensin-converting enzyme 2 (ACE2). ACE2 is known to facilitate entry of SARS-CoV-2 into host cells.
A 2018 study found that vitamin D supplementation can inhibit ACE2 expression in the kidneys, so vitamin D can reduce the expression of ACE2 in the kidney tubule cells, thus preventing the virus from entering the cell and protecting the kidneys from diabetes patients.
Angiotensin 2 (Ang2) is a natural hormone that raises blood pressure. ACE2 helps break down Ang II and thus lowers its levels.
COVID-19 infection can lower ACE2 level, which leads to excessive accumulation of Ang II. High levels of Ang II can cause acute respiratory distress syndrome and heart injuries. Renin, a protein excreted by the kidneys, can enhance Ang II accumulation.
A 2015 study found that mice without a receptor Vitamin D It increased levels of renin and ang2, and supplementing with vitamin D could inhibit the inflammatory activity of Ang 2 by suppressing the release of renin in patients with COVID-19 and reducing the risk of developing acute respiratory distress syndrome and heart problems.-
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Thus vitamin D could play a role in increasing the risk, mortality and severity of COVID 19 infections.
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