/data/photo/2020/09/25/5f6dbdc217290.jpg "Covid-19 Kills Some, Studies Show The Immune System Can Turn The Page all")
KOMPAS.com- For some people Covid-19, this new disease does not cause severe illness and heals quickly.
However, not a few patients also have to feel severe pain, even making this disease very deadly at times corona virus starts infecting the body.
Launch Science Alert, Friday (25/9/2020), two Education recently identified mechanisms immune system important that can help explain why the virus is so deadly, but only in some people.
Because, among the millions of lives lost due to Covid-19, there are things that are difficult to understand, namely when someone with a healthy body is young, but seems to be very vulnerable to infection with the new corona virus, SARS-CoV-2.
This research helps explain several things, such as why men are more vulnerable than women.
Also read: Russian Scientist Report Corona Vaccine Responds to Immunity
One research paper suggests that interferon type 1 (IFN) plays an important role in the difference in Covid-19 outcomes.
IFN is a protein produced by infected cells to help stop the spread of anything that infects them. However, for some people, this protein actually has other effects that are bad for the body.
One study showed that more than 10 percent of healthy people who end up with severe Covid-19 symptoms have antibodies that can attack the patient’s own IFN and stop it from fighting the SARS-CoV-2 virus.
“These findings provide strong evidence that interferon type 1 interference is common the cause of Covid-19 aggravating the condition and life-threatening, “said doctor Jean-Laurent Casanova, head of the St. Giles Infectious Diseases Human Genetics Laboratory at The Rockefeller University.
Also read: Scientists Find Evidence that Part of the Immune System Can Make Covid-19 worse
Dr Casanova said at least the theory could provide an understanding of efforts to solve the interferon problem with existing treatments and interventions.
Immune system sabotage on IFN
Casanova and her team identified antibodies that mistakenly neutralize one or more IFN proteins in the body in at least 101 of the 987 Covid-19 patients studied in this study.
Researchers say that this is not the first time they have seen the immune system sabotage itself and stop interferons from doing their job of fighting viral attacks.
In some cases bacterial infections are caused by, for example, species Staphylococcus, often worsening when the body’s production of antibodies turns against its own interferon defenses.
Such sabotage has been noted in people treated with interferon for hepatitis infection, as well as in women with autoimmune lupus.
The findings have been published in the journal Science This, may have helped explain why for some people Covid-19 infecting their bodies can be so deadly.
Thanks to these studies, at least there are efforts to provide appropriate means of treatment, and can better identify which population is most at risk of the disorder.
Also read: Study: The Common Flu Trains Your Immune System To Recognize Covid-19
Education is considered to have helped explain mystery the SARS-CoV-2 virus is puzzling experts at this time.
“Interestingly, 94 percent of the patients with these neutralizing auto-antibodies are male. This also explains why men are more susceptible to severe Covid-19,” said Stuart Tangye, head of the Oceania node for Covid Human Genomic Effort.
While other studies looked at hospitalized patients with severe symptoms, some of them were in their 20s.
Researchers tried to compare the genes of 659 patients with life-threatening cases of Covid-19 with 534 people who had asymptomatic or mild infections. They identified 13 abnormalities in a sequence known as integral to IFN’s anti-influenza activity.
Also read: Australian Experts Reveal How Your Immune System Fights Covid-19
This ‘loss of function’ mutation was seen in at least 3.5 percent. The genetic mutation stops the IFN from working properly.
“The way SARS-CoV-2 affects people differently is confusing. The virus can cause asymptomatic infection, it can go away quietly, but it may also kill within a few days,” said medical geneticist John Christodoulo of the Murdoch Children’s Research Institute in Australia.
Christodoulo said the changes jeopardized their ability to protect against Covid-19 infection, by interfering with the body’s ability to make interferon type 1 (IFN).
The two studies fill an important part of the mystery of the corona virus, namely to explain how it attacks and destroys the body in strange ways.
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