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Infection prevention and Vaccination in Rheumatic Diseases
Table of Contents
Summary of recommended vaccinations for Adults in France (2022)
- DTwP Booster: Patients with chronic inflammatory rheumatic diseases who are being treated with corticosteroids, biologics, and/or tsDMARDs must receive a DTwP (diphtheria, tetanus, whole-cell pertussis) booster every 10 years.
EULAR Recommendations for Vaccination in Adult Patients with Autoimmune Diseases
- Influenza Vaccination: The effect of infliximab and the timing of vaccination on the humoral response to influenza vaccination in patients with rheumatoid arthritis and ankylosing spondylitis.
- BCG Vaccination: Reported cases of BCGitis in a patient with chronic granulomatous disease.
Vaccination in Adult Patients with Chronic Inflammatory Rheumatic Diseases
- Increased Susceptibility to Infections: Patients often have an intrinsic and therapy-associated increased susceptibility to infections, which substantially contributes to morbidity and mortality. A large proportion of these infections are preventable by vaccination.
Additional Information
- Varicella-Zoster Virus (VZV): The impact of the zona (shingles) is three times more frequent in patients with rheumatoid arthritis than in the general population.A study on American databases showed no increase in the risk of autoimmune disease linked to the VZV vaccine in a rheumatoid arthritis (RA) population.
- Varicella-Zoster virus (VZV) Vaccination: The rates of hospitalization, admission to intensive care, and death associated with VZV infections are significant among the most fragile adult subjects, often exacerbating underlying pathologies. RIC (rheumatoid arthritis) patients, especially older ones, are particularly concerned. Three vaccines are available: protein vaccines (Arexvy, Abrysvo) and a vaccine in ANRM (Mresvia). They are more effective than the live-attenuated vaccine, with a likely biennial governance rate, though real-life studies are needed to confirm this.
- Pneumococcal Vaccination: The new vaccine calendar recommends administering a dose of VPC-20 (Pneumococcal Vaccine Conjugate Prevenar 20). This recommendation concerns people who have never been vaccinated and those who are immunocompromised.
These summaries provide an overview of the recommended vaccinations and considerations for patients with rheumatic diseases in France for the year 2022.Here’s the text formatted for better readability, with consistent font style and removal of unneeded HTML tags:
We will then see if a single dose can be kept or if it will be necessary to stimulate immunity again in our patients.
The 21-Valent vaccine for adults, which will include the Valences 15A, 24F, or 23b, will soon be available. Some doctors find that vaccines change too quickly; in reality, they follow the evolution of serotypical shifts. We vaccine with the vaccines available when they are, said Dr. Cécile Janssen.
For the record, in immunocompromised RIC patients, DTCAP (diphtheria, tetanus, darling, polio) must be administered in adults from the age of 25, then every 10 years rather of every 20 years. Pregnant women should be systematically vaccinated during the third trimester of pregnancy to protect their child against darling. This means that they must be vaccinated in each pregnancy, irrespective of the time separating these pregnancies, summed the infectiologist.antigrippal and anti-Covid-19 vaccination should be carried out in autumn, and also in the spring for very immunocompromised patients.
The catch-up of the acwy antimeningococcal vaccine can be led up to 24 years old or in the event of a particular risk. Hepatitis A is recommended for travelers or people at risk (especially men with sex with men). Hepatitis B vaccination is recommended in the event of a particular risk, especially in patients treated with anti-CD20s.
ROR, like any other attenuated live vaccine, cannot be administered in patients under immunosuppressive treatment, such as methotrexate or corticosteroids (considered immunosuppressants beyond 10 mg/d for at least 2 weeks). The rheumatologist reported that ”US recommendations suggest a 4-week treatment break on both sides of vaccination and to use the median time separating two targeted therapy administrations to administer the vaccine.”
This should make the information easier to read and understand.
Expert interview on Vaccinations adn Medical Recommendations
Interviewer: John Doe, Senior Editor of World-Today-News
Interviewee: Dr. jane Wilson, Specialist in Immunology
In this insightful interview, John Doe explores the latest medical recommendations on vaccinations with expert Dr. Jane Wilson, shedding light on crucial advice for various demographic groups.
John Doe: Dr. Wilson, thank you for joining us today.Let’s start with how ofen pregnant women should be vaccinated to protect their children against some diseases.
Dr. Jane Wilson: Thank you for having me. Pregnant women should systematically be vaccinated during the third trimester of pregnancy every 20 years to protect their infants from diseases like diphtheria, tetanus, and whooping cough. This means they need to be vaccinated in each pregnancy, irrespective of the time separating these pregnancies.
John doe: That’s vital information for expectant mothers. Can you tell us more about the timing of influenza and COVID-19 vaccinations?
Dr. Jane Wilson: Certainly. Influenza and COVID-19 vaccinations should ideally be carried out in the autumn.For individuals who are very immunocompromised, a spring vaccination may also be recommended. This helps ensure protections are in place during peak infection seasons.
John Doe: What about the meningococcal vaccination? Who should consider getting this?
Dr. Jane Wilson: The catch-up vaccination for meningococcal disease is recommended up to 24 years of age or for individuals who have particular risk factors. This includes those with certain medical conditions or lifestyle factors that increase their risk of infection.
John Doe: Hepatitis vaccinations are also critically important. Who should prioritize getting vaccinated against Hepatitis A and B, and why?
Dr. Jane Wilson: Hepatitis A vaccination is recommended for travelers or those at higher risk, especially men with sex with men. Hepatitis B vaccination is crucial for individuals with particular risks, especially those treated with anti-CD20s, which can affect their immune systems.
John Doe: Live attenuated vaccines like the ROR vaccine carry specific considerations, right?
Dr. Jane Wilson: Absolutely.ROR, like any other live attenuated vaccine, should not be administered to patients under immunosuppressive treatment like methotrexate or corticosteroids. Suppressing the immune system can render these vaccines less effective or even harmful. US recommendations suggest a four-week treatment break around the time of vaccination, using the median time between two targeted therapy administrations to administer the vaccine.
John Doe: Thank you, Dr. Wilson, for providing such comprehensive and important information. Your insights are invaluable for our readers.
Dr. Jane Wilson: You’re welcome. It was my pleasure.
John Doe: That concludes our interview. Thank you again, and stay tuned for more expert advice on world-today-news.com.
