Calabrian Researcher’s Breakthrough Offers Hope in Lung Cancer Fight
Dr. Marco Fiorillo, a 38-year-old researcher from Calabria, Italy, has returned to his alma mater, the University of Calabria (Unical), after eight years of postdoctoral research at the Universities of manchester and Salford. His return exemplifies a growing trend of “brain repatriation,” fueled by Unical’s recruitment initiatives aimed at attracting top talent back to Italy. Now a professor and researcher in Biochemistry in the Department of Pharmacy and Health and Nutrition Sciences, Dr. Fiorillo is making significant strides in the fight against lung cancer.
Targeting Cancer’s Weaknesses: A Novel Approach
Dr. Fiorillo’s research focuses on a critical vulnerability in lung cancer cells: their mitochondria.”It’s based on mitochondria – small cellular organelles that allow cells to breathe, but which also allow the survival of very risky tumor cells, called cancer stem cells, resistant to anticancer treatments,” he explained in a recent interview on LaCTv’s “Inside the News.” His work centers on mutations in the LKB1 tumor suppressor gene, which leads to significant metabolic changes making tumors resistant to standard therapies. “Due to this mutation, the tumor becomes resistant to standard therapies. We have developed two new compounds that have proven effective in selectively targeting thes mutated tumor cells,” he stated.
In collaboration with researchers in Greece and England, Dr. Fiorillo’s team has demonstrated the effectiveness of these compounds in reducing mitochondrial functionality specifically in tumor cells, leaving healthy cells unharmed. ”These are new therapeutic agents which could combat advanced tumors and resistant to conventional treatments, reducing relapses and preventing the formation of metastases,” he highlighted. This precision oncology approach represents a significant leap forward in cancer treatment.
Hope for the Future: A Message to Aspiring Scientists
Dr. Fiorillo’s work is currently in the preclinical phase, undergoing rigorous testing to ensure safety and efficacy before human trials. His success story serves as an inspiration, particularly for young scientists. He concluded his interview by encouraging students to pursue their passions and take advantage of the opportunities available at the University of Calabria and beyond. His research offers a beacon of hope in the ongoing battle against lung cancer, showcasing the power of innovative research and the importance of supporting scientific advancements.
To watch the full interview on LaCTv, click here.
