City of Hope Breakthrough: New Target Identified in Blood Cancer’s Immune Evasion
Researchers at City of Hope National Medical Center have made a significant discovery in the fight against blood cancers. Their findings, published in the journal Cell, reveal a protein, YTHDF2, that enables cancer cells to cleverly evade the body’s immune defenses, specifically those deployed by CAR-T cell therapy.
CAR-T cell therapy, a revolutionary immunotherapy, reprograms a patient’s own T-cells to target and destroy cancer cells. Though, some cancers develop resistance, a phenomenon known as “antigen escape,” where cancer cells reduce or eliminate the markers CAR-T cells use for identification.
The City of Hope study demonstrates that YTHDF2 plays a crucial role in this evasion. The protein boosts cancer cell energy production, fueling rapid growth. Furthermore, it helps cancer cells suppress the very antigens CAR-T cells rely on for targeting.
“This research is a game-changer,” says Dr. [insert Name and Title of relevant researcher at City of Hope, if available]. “Understanding how YTHDF2 contributes to cancer cell survival and immune evasion opens up exciting new avenues for treatment.”
Building on this discovery,the research team developed CCI-38,a drug designed to inhibit YTHDF2’s function. Preclinical testing showed promising results, indicating CCI-38’s potential to slow cancer cell growth and enhance the effectiveness of CAR-T therapy.
City of Hope, with its extensive experience in CAR-T cell therapy—treating over 1,600 patients as the late 1990s—is well-positioned to advance this research. The potential applications extend beyond blood cancers,possibly impacting the treatment of other cancers and autoimmune diseases.
The team has filed a patent for their findings and plans to conduct further research on CCI-38’s safety and efficacy, exploring additional strategies to neutralize YTHDF2 in cancer cells. Clinical trials are on the horizon, offering a beacon of hope for patients battling these challenging diseases.
New Mobile App and Exciting Contest Launched
get ready to experience the future of mobile technology! A brand-new submission has just been released, offering users a streamlined and innovative way to[[insert brief description of app functionality, e.g., manage finances, connect with friends, play games]. And that’s not all – to celebrate the launch, an exciting contest is underway, offering participants a chance to win remarkable prizes.
The developers are confident that this app will revolutionize[[insert relevant area, e.g., personal finance management, social networking, mobile gaming]. “We’ve poured our hearts and souls into creating an app that is both user-friendly and incredibly powerful,” said [[insert name and title of spokesperson,if available]. “We beleive this will be a game-changer for[[target audience].”
But the excitement doesn’t stop there. To mark this momentous occasion, the developers are hosting a contest with amazing prizes up for grabs.Participants can enter by[[explain how to enter the contest, e.g., downloading the app, sharing on social media, referring friends]. The contest runs until[[insert contest end date].
Don’t miss out on this incredible opportunity! “We’re thrilled to offer these amazing prizes to our users as a thank you for their support,”[[insert quote from a developer or spokesperson,if available,or else remove this paragraph].
Ready to download the app and enter the contest? Click the links below:
Stay tuned for updates and announcements on our social media pages![[Insert links to social media pages]
