Kabar6-By taking genes from single-celled creatures, and adding them to mouse cells to regenerate stem cells, a team of scientists created mice using ancient genetics that are older than any other animal life .
The gene was then inserted into the developing embryo to create a living, breathing mouse. Millions of years ago, before the appearance of multicellular organisms, there were single-celled organisms on planet Earth. Some of these, called choanoflagellates, are considered the closest living relatives of animals.
Based on new research, reported by PurdueExponent, their genomes have different versions of the Sox and POU genes, which are known to stimulate the formation of stem cells in mammals and, until now, were believed not to. they were present only in animals. This was now discovered in single-celled organisms and was later used by scientists to reprogram mouse cells.
“By successfully creating mice using molecular tools derived from our single-celled relatives, we are seeing a remarkable continuity of function over nearly a billion years of evolution,” explained study author Dr. Alex of Mendoza.
Adding, “This study means that the key genes involved in the formation of stem cells may have originated much earlier than the stem cells themselves, possibly helping to prepare the a way for the diverse life we see today.”
The choanoflagellate Sox gene was introduced into mouse cells, where it replaced the existing Sox2 gene, and in the process turned the cells into induced pluripotent stem cells (iPSCs ). These cells can develop into any type of cell in the body.
When scientists inserted iPSC into mouse embryos, they created so-called chimeras, which are animals whose cells are different from each other and contain two different sets of DNA.
The new mice had characteristics of iPSC and donor embryos and had dark eyes and patches of black fur, proving that old genes had affected the development of the animals. (ilj/bbs)
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2024-11-27 00:49:00
#Ancient #Genetics #Scientists #Create #Living #Breathing #Mice #Kabar6.com
Given the groundbreaking nature of this discovery, what ethical guidelines and regulations should be established to govern future research on re-engineering organisms with ancient genetic material?
## World Today News Interview: Re-engineering Mice with Ancient Genes
**Introduction:**
Welcome to “World Today News,” I’m your host [Host Name]. Today, we’re diving into fascinating new research that has taken a leap back in time, literally. A team of scientists has successfully incorporated ancient genes from single-celled organisms into mouse cells, leading to the creation of living mice. This groundbreaking study opens up a world of possibilities in understanding evolution and the very origins of stem cells. Joining us today to discuss this remarkable feat are Dr. [Guest 1 Name], a renowned geneticist, and Dr. [Guest 2 Name], an ethicist specializing in the implications of emerging biotechnology.
**Section 1: Unlocking the Past through Genes**
**Host:** Dr. [Guest 1 Name], can you elaborate on how this discovery challenges our understanding of the evolutionary timeline of stem cells?
**Dr. [Guest 1 Name]**:
(Elaborate on the history of stem cell research and how this specific discovery sheds light on the ancient origins of these crucial cells. Discuss the significance of finding Sox and POU genes in single-celled organisms, previously thought to exist only in animals.)
**Host:** This is truly remarkable! Dr. [Guest 2 Name], what are the ethical considerations we need to be aware of when wielding such powerful genetic tools inherited from ancient life forms?
**Dr. [Guest 2 Name]**:
(Discuss the ethical implications of altering the genetic makeup of living beings using ancient genetic material. Explore the potential benefits and risks associated with this technology, raising questions about the line between scientific exploration and ethical boundaries.)
**Section 2: The Power of Chimeras and Beyond**
**Host**: Dr. [Guest 1 Name], what is the significance of creating chimeric mice in this experiment?
**Dr. [Guest 1 Name]:**
(Explain the process of creating chimeras and the role they play in understanding how the ancient genes influence development. Highlight the observable traits in the chimeric mice and the evidence suggesting successful integration of the ancient genes.)
**Host:** Dr. [Guest 2 Name], how do you see this discovery impacting future research and medical advancements?
**Dr. [Guest 2 Name]:**
(Speculate on the future applications of this research, particularly in regenerative medicine and stem cell therapies. Discuss the potential for developing new treatments for debilitating diseases and the ethical considerations associated with such advances.)
**Section 3: Looking Ahead: A Future Shaped by Ancient Genes?**
**Host:** Both of you, looking forward, what are the biggest questions this discovery raises for researchers and society as a whole?
**(Both guests share their final thoughts on the broader implications of this groundbreaking research. Encourage discussion on the future direction of this field and the need for ongoing ethical considerations and open dialog.)
**Closing:**
Thank you both for this insightful discussion. This is undoubtedly a pivotal moment in our understanding of life’s building blocks, and we look forward to seeing how this discovery continues to unfold. Remember to leave your comments and questions below, and tune in next time for more fascinating explorations on ”World Today News.”
