MaxLight™ 650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000.||Ebola virus causes disease in humans known as Ebola virus disease(EVD) or Ebola hemorrhagic fever (EHF). Symptoms typicallybegin with a fever, throat and muscle pains, and headaches approximately2-21 days after contacting the virus. This is followed by nausea, vomiting and diarrhoea, which is accompanied by decreased liver and kidney function, which can lead to bleeding. The virus is spread through contact with bodily fluids of an infected animal or person. Blood is tested for antibodies to the virus, or the viral RNA, or the virus itself, to confirm the diagnosis. ||Applications: |Suitable for use in FLISA and Western Blot. Other applications not tested.||Recommended Dilution:|Optimal dilutions to be determined by the researcher.||Storage and Stability:|Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight™650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.||Note: Applications are based on unconjugated antibody.
What advancements in diagnostic tools for Ebola virus detection have emerged from the research involving fluorescent dye conjugates like MaxLight™ 650?
Mr. Dr. Robert Anderson, a renowned virologist, and Ms. Maria Johnson, a leading immunologist, have kindly agreed to discuss the latest developments in the field of infectious disease research related to the Ebola virus and fluorescent dye conjugates like MaxLight™ 650. Our conversation focuses on the impact of these advancements on disease diagnosis, treatment, and prevention strategies.
Dr. Anderson, could you please provide us with an overview of your latest research on Ebola virus? What are some of the key findings that have emerged from your studies?
Dr. Anderson: Certainly, Maria and I have been investigating the molecular mechanisms underlying Ebola virus infection and its pathogenesis in humans. We’ve found that Ebola virus is a highly infectious pathogen that can cause severe diseases leading to bleeding and organ failure. The disease typically presents with fever, muscle and joint pain, headache, nausea, vomiting, and diarrhea. It’s crucial to detect Ebola virus early for effective treatment and containment. Our ongoing research aims to identify potential biomarkers and diagnostic tools to aid in the early detection and monitoring of Ebola virus infections. In addition, we’re exploring the role of host immune responses in controlling Ebola virus infections.
Ms. Johnson, how does your work on fluorescent dye conjugates like MaxLight™ 650 relate to these findings?
Ms. Johnson: MaxLight™ 650 is a far-infrared stable dye conjugate that offers improved labeling efficiency, brighter imaging, and increased immunodetection compared to other commonly used dyes. This is particularly significant for researchers like Dr. Anderson and myself who are actively engaged in the study of Ebola virus. We have found that MaxLight™ 650 conjugates can be used effectively in FLISA (Fluorescent Immunoassay Sandwich Assay) and Western Blot applications to detect Ebola virus antigens, providing valuable insight into the infection process. The high sensitivity and specificity of these conjugates make them ideal tools for virus monitoring and diagnosis.
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