[조수완 하이닥 건강의학기자] As the number of patients with diabetes and high blood pressure increases, kidney disease is also increasing rapidly. However, once the podocytes of the glomeruli, which play a ‘filter role’ in the kidneys, are damaged, they do not recover easily, making treatment difficult. However, recently, research results showing that a fasted simulation diet (FMD) is effective in restoring kidney function and slowing the progression of the disease are attracting attention.
The results of this study (Diet specific for kidney mimics promoting podocyte reprogramming and restoring kidney function in glomerulopathy) were published in the international academic journal ‘Science’.
A research team at Children’s Hospital Los Angeles, USA, applied a low-salt simulated diet (LS-FMD) to rats with chronic kidney disease over six cycles. FMD is a diet that tricks the body into thinking it is fasting by reducing daily calorie intake to around 700 kcal and restricting protein and carbohydrate consumption for five days a month.
The results of the study showed that mice treated with FMD recovered kidney function and regenerated damaged podocytes. The albumin-creatinine ratio and blood urea nitrogen (BUN) levels were significantly improved, and kidney tissue damage was also significantly reduced.
The research team conducted a preliminary clinical trial on 13 patients with chronic kidney disease. As a result of performing FMD 5 days a month for 3 months, proteinuria levels decreased and vascular function improved. The research team assessed that FMD was effective in helping podocyte regeneration and delaying the deterioration of kidney function.
“We have demonstrated that FMD can slow the progression of kidney disease through changes in gene expression, and further studies with more patients are needed,” said study co-author Dr. Valter Longo. The research team plans to apply FMD to more patients with kidney disease in the future to look at the long-term effects.
Soo-wan Jo, Hidoc Health and Medical Reporter [email protected]
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2024-11-08 12:30:00
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